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ISAP Workshop at the WCDA: Workshop 1
Wednesday,
September 08, 2004, 08:00 AM – 10:30 AM
Preclinical Pharmacokinetics and Pharmacodynamics of
Anti-infective Agents
Conveners:
Johan W. Mouton, MD, PhD; Canisius Wilhelmina Ziekenhuis,
Nijmegen, Netherlands.
Hartmut Derendorf, PhD; Univ. of Florida, Gainesville, FL,
USA.
Faculty:
Otto Cars, MD, MPH; Uppsala Univ. Hosp., Uppsala, Sweden.
William A. Craig, MD; William S. Middleton Mem. VA Hosp., Madison, WI, USA.
Hartmut Derendorf,
PhD; Univ. of
Florida, Gainesville, FL, USA.
Johan W. Mouton, MD, PhD; Canisius Wilhelmina Ziekenhuis, Nijmegen,
Netherlands.
Ursula Theuretzbacher, PhD;
Antibiotics Center, Vienna, Austria.
Objectives:
- Gain insight
in pharmacokinetic and pharmacodynamic concepts of antimicrobial efficacy
- Application
of in vitro models and animal models in pharmacodynamic research
- The
limitations and use of serum and tissue concentrations
- Know how to
calculate pharmacokinetic and pharmacodynamic parameters and interpret the
results
- Drug resistance in
vitro
Intended
Audience: Medical microbiologists, infectious
diseases specialists, pharmacologists, and others interested
Level: Beginning
Prerequisites:
None
Program: Introduction
to PK/PD (Derendorf)
PK/PD indices (Mouton)
Protein Binding/Tissue Distribution (Theuretzbacher)
In vitro models (Mouton)
Animal models (Craig)
In vitro resistance (Cars)
(Coffee
between 10:30 AM and 11:00 AM)
ISAP Workshop at the WCDA: Workshop 2
Wednesday, September 08, 2004, 11:00 AM – 01:30 PM
Clinical Relevance of
Pharmacokinetics and Pharmacodynamics of Anti-infective Agents
Convener:
Johan W. Mouton, MD, PhD; Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands.
Faculty:
Otto Cars, MD, MPH; Uppsala Univ. Hosp., Uppsala,
Sweden.
George L. Drusano, MD;
Albany, NY, USA.
Johan W. Mouton, MD, PhD; Canisius Wilhelmina Ziekenhuis, Nijmegen,
Netherlands.
Markus Mueller, MD; Univ. Vienna, Vienna, Austria.
Paul M. Tulkens, MD;
Univ. Louvain, Brussels, Belgium.
Objectives:
- Gain insight
in the clinical significance of pharmacokinetic and pharmacodynamic
modeling of antimicrobials
- Application
of preclinical PK/PD into clinical drug development
- PK/PD of
antivirals and antifungals
- Assessment
of drug exposure at the site of infection
- Clinical
drug resistance
Intended
Audience: Medical microbiologists, infectious
diseases specialists, pharmacologists, and others interested
Level: Intermediate/Advanced |
Prerequisites:
None.
Program: Clinical
applications of PK/PD (Tulkens)
Drug exposure at infection site (Mueller)
PK/PD of antivirals (Drusano)
PK/PD of antifungals (Mouton)
Clinical resistance (Cars)
Clinical dose optimization (Tulkens)
(Lunch between 01:30 PM and 02:30 PM)
ISAP Workshop at the WCDA: Workshop 3
Wednesday, September 08, 2004, 02:30 PM – 05:00 PM
PK/PD Modeling of Anti-infective Agents
Convener:
Hartmut Derendorf, PhD; Univ. of Florida, Gainesville, FL, USA.
Faculty:
William A. Craig, MD; William S. Middleton Mem. VA Hosp., Madison, WI, USA.
Hartmut Derendorf, PhD; Univ. of Florida, Gainesville, FL, USA.
George L. Drusano, MD; Albany, NY,
USA.
Alan Forrest, PhD; SUNY Buffalo, NY, USA.
Objectives:
- MIC based
PK/PD modeling in vitro and in animals
- PK/PD based
on kill curves
- Population
PK/PD of anti-infective agents
- Monte Carlo
Simulations
- Integration
of preclinical and clinical PK/PD
Intended
Audience: Medical microbiologists, infectious
diseases specialists, pharmacologists, and others interested
Level: Intermediate/Advanced |
Prerequisites:
None.
Program: In
vitro MIC based PK/PD (Mouton)
PK/PD in animals (Craig)
PK/PD based on kill curves (Derendorf)
Population PK/PD (Forrest)
Modeling of anti-infective activity (Forrest)
Monte Carlo Simulations (Drusano)
(End at about 05:00 PM)