Poster Presentations Antiinfectives - new and known synthetic compounds Antiinfectives - new and known non-synthetic compounds Clinical studies and use of antibiotics Antivirals - clinical studies Antifungals - clinical studies Antimalarial compounds - clinical studies Pharmacokinetics and tissue penetration of antiinfectives Pharmacodynamics and experimental therapy of antiinfectives Microbiology Adverse events, interactions and toxicity of antiinfectives Mechanisms of pharmacological and biochemical action of antiinfectives In vitro action of antimalarials Antiviral agents Resistance to antiinfectives Analytical techniques Antineoplastic agents - new and known synthetic compounds Antineoplastic agents - new and known non-synthetic compounds Antineoplastic agents - clinical studies Pharmacokinetics and tissue penetration of antineoplastic agents Mechanism of tumor development and growth Mechanisms of action of antineoplastic agents including resistance Vaccination Mechanisms of pharmacological importance Diagnostic tests in cancer / adverse events of cancer treatment Adverse events of antineoplastic compounds Blood brain barrier Targeted delivery of antineoplastic agents Role of cells and their staining by dyes Agents involving the immune system About mechanisms and Magic Bullets Poster Presentations Category: Antiinfectives - new and known synthetic compounds 037 ANTIMICROBIAL ACTIVITIES OF SOME TETRAHYDRONAPTHALENE-BENZIMIDAZOLE DERIVATIVES. Z. ATES-ALAGÖZ1, S. YILDIZ2, E. BÜYÜKBINGÖL1 Department of Pharmaceutical Chemistry1, Department of Microbiology2, Ankara University, Faculty of Pharmacy, Tandogan, Ankara, Turkey. 057 Novel Pyrazole derivatives as Anti-inflammatory-Antibacterial Agents; Synthesis and Optimum Dosing in Experimental animals. Adnan A. Bekhit1, Elsayed Aboulmagd2, Azza M. Baraka3 1Department of Pharmaceutical Chemistry, 2Department of Microbiology Faculty of Pharmacy, 3Department of Pharmacology, Faculty of Medicine University of Alexandria, Alexandria, Egypt. 271 New Targets for Salmonella Treatment: RpoE Regulon of Salmonella typhimurium. KORMANEC J1, MITICKA H1, ROWLEY G2, REZUCHOVA B1, ROBERTS M2 1 Institute of Molecular Biology, Centre of Excellence for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic; 2 Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow, U.K. 503 Titanium Plate Anodized by Discharging in NaCl Solution Exhibits Antibacterial Activity against Oral Bacteria. SHIBATA Y. 1, TAKASHIMA H. 1, MIYAZAKI T. 1 1Department of Oral Biomaterials and Technology, Showa University School of Dentistry, Tokyo, Japan. 088 Synthesis and Antimicrobial Activities of Some New Flavonyl Pro-drug Esters of Ampicillin. CEYLAN-ÜNLÜSOY Ma, ALTANLAR Nb, ERTAN Ra Ankara University, Faculty of Pharmacy, Departments of aPharmaceutical Chemistry, bMicrobiology, Tandogan, Ankara, Turkey. 396 SYNTHESIS AND POTENT ANTIMICROBIAL ACTIVITY OF SOME NOVEL 4-(5,6-DICHLORO-1H-BENZIMIDAZOL-2- YL)-N-SUBSTITUTED BENZAMIDES. Seçkin Özden a, Hacer Karatas a, Sulhiye Yildiz b, Hakan Göker a a Department of Pharmaceutical Chemistry, b Department of Microbiology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara-Turkey. 007 Synthesis and Biological Activity of CMP-KDO Synthetase Inhibitors in Lipopolysaccaride Biosynthesis of Gram-negative Bacteria. ADACHI H1, KONDO K1, DOI H1, KOJIMA F1, ISHINO, K2, HOTTA K2, UMEZAWA Y1, NISHIMURA Y1 1Mirobial Chemistry Research Center, Tokyo, Japan; 2National Institute of Infectious Diseases, Tokyo, Japan. 019 Synthesis & Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazol-5-Carboxamidines. GOKER, H a., ALP, M a., YILDIZ, S b. a Department of Pharmaceutical Chemistry, b Department of Microbiology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara-Turkey. 590 Structure and Blood Schizontocidal Activity of Various Analogues of Lumefantrine in Plasmodium falciparum, in vitro. Woitsch B1, Wernsdorfer WH1,4, Allmendinger T2, Sirichaisinthop J3, Wernsdorfer G4 1Division of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria; 2Department of Chemical and Analytical Development, Novartis, Basel, Switzerland; 3Bureau of Vector-Borne Disease Control, Ministry of Public Health, Nonthaburi, Thailand; 4Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. 490 Effectiveness of "Quinoxaline derivatives" in vitro against Mycobacterium tuberculosis and non tubercolous Mycobacteria strains. Sechi LA., Pinna A.,* Deriu A., Molicotti P., Carta A.,° Paglietti G.,° Zanetti S Department of Biomedical Sciences, University of Sassari, Italy *Department of Ophthalmology, University of Sassari °Department of Chemistry, University of Sassari. 011 Zalcitabine (ddC) Induces Cellular Resistance Affecting its Antiviral Activity. AGARWAL RP, SARKAR M, HAN T Sylvester Comprehensive Cancer Center, Department of Medicine, University of Miami, Miami, Florida, USA. 552 Water soluble phenoxazines exert antimicrobial effects on poliovirus, bovine parvo virus, Helicobacter pylori and non- tuberculotic mycobacteria. TOMODA A1, YAMAGUCHI T2, KAMIYA S3 1Department of Biochemistry, Tokyo Medical University; 2Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, 3Department of Infectioius Diseases, Kyorin University School of Medicine, Tokyo, Japan. 166 Antileishmanicidal Properties of Ferrocenyl Chalcones. WU X1, GO ML1 , KAYSER O2, KIDERLEN AF3 1 National Univerity of Singapore, Singapore; 2 Rijksuniversiteit Groningen, The Netherlands, 3 Robert Koch Institut, Germany. 167 SYNTHESIS AND POTENT ANTIMICROBIAL ACTIVITY OF SOME NOVEL ALKYL 1H-BENZIMIDAZOLE-5- CARBOXYLATES CARRYING AMIDE AND AMIDINES. Hakan Gökera, Seçkin Özdena, Sulhiye Yildiz b a Department of Pharmaceutical Chemistry, b Department of Microbiology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara-Turkey. 190 Effect of Nitric Oxide Synthase Inhibitors in Schistosoma japonicum Infection: Killing Effect of D-NAME. HIRATA M1, HIRATA K2, HARA T1, FUKUMA T1 1Kurume University, Kurume, Japan; 2Kyushu University, Fukuoka, Japan. Category: Antiinfectives - new and known non-synthetic compounds 089 COLOMYCIN – REVISITED. CHATTOPADHYAY B1, ALI S2 1Department of Medical Microbiology and 2Department of Pharmacy, North Middlesex University Hospital, London, United Kingdom. 138 Development of New Cultivation Strategy to Improve the Production of Natamycin and to Minimize the Risk of Antibiotic Degradation During Submerged Cultivation of Streptomyces natalensis. EL-ENSHASY, H.A.1; FARID, M.A.2; EL-DIWANY, A.I.2 AND EL-SAYED, E.A.3 1 Mubarak City for Scientific Research, Alexandria, Egypt, 2 National Research Centre, Cairo, Egypt, 3 GBF, Braunschweig, Germany. 182 Antibiotic Resistance of staphylococcus aureus Isolated from an Aquatic Environment in Lebanon. Steve Harakeh†, Hadi Yassine†, S. Hajjar† and Mutasem El-Fadel‡ †Department of Biology, ‡Department of Civil and Environmental Engineering. American University of Beirut, Beirut, Lebanon. 216 Antimicrobial Activity of Essential Oils of Nigella sativa and Artemisia sieberi. MOHAMMAD JALALI, DARYOUSH ABEDI, GHANNADI ALI REZA MOHAMMAD REZA BAGHJERINEJAD Isfahan University of Medical Sciences. 349 Investigation of Antibacterial Potentiality of Methanol Extraction from Fungus Ganoderma applanatum. Mohammad-Fata Moradalia, Hossien Mostafavi b, Ghorban- Ali Hejaroudea Mehrdad Abbasic, Shirin. Ghodsa and Ali Salahid aPlant Protection Dept., Faculty of Agriculture, Tehran University, Karaj, Iran, bNational Research Center of Genetic Engineering and Biotechnology, Tehran, Iran, cPlant Pest & Diseases Research Institute, Tehran, Iran , dResearch Institute of Forests & Rangelands. 021 ANTILISTERIAL ACTIVITY OF BALLOTA SPECIES GROWING IN TURKEY. Nurten ALTANLAR1, Gülçin SALTAN ÇITOGLU2, Betül SEVER YILMAZ2 Departments of Pharmaceutical Microbiology1 and Pharmacognosy2 Ankara University, Faculty of Pharmacy, Ankara, Turkey. 111 Antifungal Flavonoid Triglycosides: Importance of the Glycosydic Haptophoric Part in Determining the Biological Activity. CURIR P1, DOLCI M2, LANZOTTI V3 1Istituto Sperimentale Floricoltura, Sanremo, Italy; 2Di.Va.P.R.A. University, Torino, Italy; 3Di.S.T.A.A.M., Molise University, Campobasso, Italy. 327 In Vitro Growth Inhibition of Dermatophytes by Some Strains of Bacillus subtilis. MELENTIEV AI1, MUCHAMADEEVA OR2, GALIMZYANOVA NF1, KUZMINA LYu1, YAKOVLEVA OV1 1Institute of Biology, Ufa Research Center RAS, Ufa, Russia; 2Ufa Dermatovenereologic Clinic, Ufa, Russia. 371 ANTIFUNGAL ACTIVITY OF Chromolaena odorata (L.) King & Robinson (Asteraceae) OF CAMEROON. A. NGONO NGANEa, F. NDIFORa, R. EBELLE ETAMEa, L. BIYITIb, P. H. AMVAM ZOLLOb & Ph. BOUCHETc aLaboratoire de Biochimie - Faculté des Sciences Douala - Cameroun. bLaboratoire de Phytobiochimie - Faculté des Sciences Yaoundé - Cameroun. cLaboratoire de Biologie Végétale et de Mycologie - U. F. R. de Pharmacie, Reims Cedex, France. 269 An antimalarial compound from Trichosanthes cucumerina. KONGTUN S1, JIRATCHARIYAKUL W1, TAN-ARIYA P2, FRAHM AW3 1Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2 Faculty of Science, Mahidol University, Bangkok, Thailand; 3Institute of Pharmacy, Freiburg University, Freiburg, Germany. 142 In vitro Pharmacodynamic Evaluation of Anti-viral Medicinal Plants using a Vector-based Assay Technique. ESIMONE CO1, GRUNWALD T1, WILDNER O1, NCHINDA G1, TIPPLER B1, PROKSCH P2 and UEBERLA K2. 1 Department of Medical and Molecular Virology,Ruhr-University, Bochum, Germany 2 Department of Pharmaceutical Biology, Heinrich-Heine University, Duesseldorf, Germany. 224 Anti-papilloma viral activity of Trichosanthes cucurmerina root. KONGTUN S1, JIRATCHARIYAKUL W1, KUNACHAK S2, FRAHM AW3, KANCHALA UTID2 1Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2 Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Institute of Pharmacy, Freiburg University, Freiburg, Germany. 422 In Vitro and In Vivo Evaluation of the Anti-prionic Activity of Newly Synthesized Congo Red Derivatives. Poli G1,3, Bareggi SR2,3, Ponti W1, 3 1Dept. of Animal Pathology, Hygiene and Veterinary Public Health; 2Dept. of Pharmacology; 3Center of Excellence on Neurodegenerative Diseases, Milan, Italy. 038 Antimicrobial and antiparasitic activity induced by Origanum minutiflorum and Angelica sinensis (Umbelliferae) essential oils, respectively, in Mediterranean aquaculture. F. ATHANASSOPOULOU*, E. KARAGOUNI** and J. PAPPAS*** *Laboratory of Ichthyology & Fish Pathology , Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece, **Laboratory of Cellular Immunology, Institut Pasteur Hellenique, Athens, Greece, ***Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Thessaly, Karditsa , Greece. 091 Dose Dependent Therapeutic Antiinfectives from Ethnomedicines of Bay Islands. D CHATTOPADHYAY CMR Virus Unit, ID & BG Hospital, Kolkata, India. 087 Studies on the Synthesis of Some New Flavone Derivatives. CEYLAN-ÜNLÜSOY Ma, BOZDAG-DÜNDAR Oa, ALTANLAR N b, ERTAN Ra Ankara University, Faculty of Pharmacy, Departments of aPharmaceutical Chemistry, bMicrobiology, Tandogan, Ankara, Turkey. 039 NEW RESEARCH ON TREATMENTS FOR PARASITIC DISEASE IN MEDITERRANEAN AQUACULTURE. F. ATHANASSOPOULOU*, I. S. PAPPAS***, E. KARAGOUNI*** *Laboratory of Ichthyology & Fish Pathology and **Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece, ***Laboratory of Cellular Immunology, Institut Pasteur Hellenique, Athens, Greece. 475 The crude latex of Crown-of-Thorns (Euphorbia milii var. hislopii) as a potent plant molluscicide and a promising alternative to schistosomiasis control: a Review of Laboratory and Field Studies in Brazil. SCHALL VT Centro de Pesquisas René Rachou - Fiocruz, Barro Preto, Belo Horizonte, MG, Brasil. 561 In Vitro Growth Inhibiting Effect of Biologically Active Substances (BAS) from Parasite and Host Origin under Fascioliasis and Trichinellosis. TSOCHEVA-GAYTANDZHIEVA NT1, TOSHKOVA RA1, NICOLOVA EB2, MIHOV LD1, PETKOVA SL2 1Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia, Bulgaria; 2Institute of Experimental Morphology and Anthropology, BAS, Sofia, Bulgaria. 362 Ruthenium and Palladium Complexes with Planar Ligands. DNA Binding Study and biological activity against Leishmania mexicana. NAVARRO Ma, BETANCOURT Aa, CORONA Oa, MARCHAN Eb aCentro de Química, IVIC, Caracas. bIIBCA-UDO, Cumaná, Venezuela. Category: Clinical studies and use of antibiotics 059 Consummation of glycopeptids in Hospital of Oran (Algeria) since the introduction of nominative dispensations. BENABDELLAH A1,KOUIAD-BELKADI S1,TAIEB Z1, AZZI N1,BENDIMERAD S1,TALEB M2 1Unit of infectious diseases.Hospital of Oran, 2Pharmacy-Hospital of Oran. 431 Misuse of antibiotics at the first contact setting: a Sri Lankan experience. Premaratna R. Halambarachchige L, Thilakaratne Y, Gunatilake S. Department of Medicine, Facutly of Medicine, University of Kelaniya, Sri Lanka. 103 Pulse ceftriaxone therapy in Lyme neuroborreliosis. GALEV A1, CHRISTOVA I2 1Clinic of Infectious Diseases, Military Medical Academy, Sofia 2National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria. 178 Concentrations of Chemokines in Cerebrospinal Fluid and Serum of Patients with Neuroborreliosis. GRYGORCZUK S1, ZAJKOWSKA J1, SWIERZBINSKA R1, PANCEWICZ S1, KONDRUSIK M1, HERMANOWSKA- SZPAKOWICZ T1 1 Medical Academy in Bialystok, Bialystok, Poland. 367 Intravenricular vancomycin for treatment of persistent methicillin resistant Staphylococcus aureus (MRSA) ventriculitis. Mirjana Nesin, Gary Laborada, Florencia Cruz Weill Medical College of Cornell University, New York City, USA. 558 Monoplegia due to brucellosis. TOPRAK O1, OZBAS G2, OZDEMIRKIRAN T3 1Internal Medicine, Government Hospital of Dogubeyazit, Agri, Turkey; 2Infectious Diseases and Clinical Microbiology, Ataturk Training and Research Hospital, Izmir, Turkey; 3Second Neurology, Ataturk Training and Research Hospital, Izmir, Turkey. 657 Treatment of Experimental Meningitis by Multidrug-Resistant Pseudomonas aeruginosa with Imipenem: Benefits From The Co-administration of Dexamethazone?. K. PAPAPETROU1, G. LAOUTARIS2, E. J. GIAMARELLOS-BOURBOULIS2, T. TSAGANOS2, F. BAZIAKA2, D. SAKAS2, H. GIAMARELLOU. 1Department of Neurosurgery & 24th Department of Internal Medicine, Athens Medical School, Greece. 181 THE EFFECTIVENESS OF FLUOROQUINOLONES IN OPHTHALMOLOGY. HANIOGLU KARGI S1, UGURBAS SH1 1 Department of Ophthalmology, Zonguldak Karaelmas University, School of Medicine, Zonguldak-Turkey. 233 Patient compliance with once-daily versus twice-daily clarithromycin in acute bacterial exacerbation of chronic bronchitis. KARDAS P1 1Medical University of Lodz, Lodz, Poland. 467 CONTINUOUS VERSUS INTERMITTENT BOLUS ADMINISTRATION OF IMIPENEM IN CRITICALLY ILL PATIENTS WITH PNEUMONIA. Sakka SG1, Glauner A1, Bulitta J2, Kinzig-Schippers M2, Sörgel F2. 1Dept. of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller-University, Jena, Germany 2Institute for Biomedical and Pharmaceutical Research, Nuremberg, Germany. 259 Histopathologic Examination For Helicobacter Pylori As A Possible Etiopathogenic Factor In Laryngeal Carcinoma. Ahmet Kizilay1, Levent Saydam2, Abdullah Aydin3, M. Tayyar Kalcioglu4, Orhan Ozturan5, N. Engin Aydin6 1,4,5Department of Otolaryngology; 5Department of Pathology; Inonu University Medical School, Malatya, 2Department of Otolaryngology, Bayindir Medical Center, Ankara; 3Department of Pathology, Gaziantep University Medical School; Gaziantep, TURKEY. 499 Prophylactic Antibiotics in Obstetric and Gynaecological Surgeries. SHARMA JB , MITTAL S All India Institute of Medical Sciences, New Delhi, India. 512 Comparative Randomized Pilot Study of Azithromycin and Doxycycline Efficacy and Tolerability in the Treatment of Prostate Infection Caused by Ureaplasma urealyticum. SKERK V1, MAREKOVIC I2, MARKOVINOVIC L1, BEGOVAC J1, SKERK V3, BARSIC N3, MAJDAK-GLUHINIC V1 1University Hospital for Infectious Diseases "Dr. Fran Mihaljevic", Zagreb, Croatia; 2Jordanovac" University Hospital for Lung Diseases, Zagreb, Croatia; 3Medical faculty, University of Zagreb, Croatia. 557 Brucella epididymoorchitis treated with a combination of three antibiotics: evaluating two cases. TOPRAK O1, OZBAS G2 1Internal Medicine, Government Hospital of Dogubeyazit, Agri, Turkey; 2Infectious Diseases and Clinical Microbiology, Ataturk Training and Research Hospital, Izmir, Turkey. 171 Bacteriophage Therapy of Urinary Tract Infections, Including Transplant Recipients. WEBER-DABROWSKA B1, BORATYNSKA M2, KLINGER M2, LORENZ J3 , LUSIAK-SZELACHOWSKA M1, GÓRSKI A1,4. 1L.Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw; 2Department of Nephrology and Transplantation Medicine, The Medical University, Wroclaw; 3Department of Urology, The Medical University, Wroclaw; 4 Department of Clinical Immunology, The Transplantation Institute, The Medical University of Warsaw, Poland. 413 Long term antibiotic treatment of acute pyelonephritis: reduction of scar formation. COLLA L1, BURDESE M1, MEZZA E1, MARCUCCIO C1, MESIANO P1, GIRAUDI R1, MARENGO M1, CONSIGLIO V1, VERAS TAVAREZ J1, BESSO L1, SEGOLONI GP1, PICCOLI GB1. Chair of Nephrology, Internal Medicine Department, University of Turin – Italy. 248 Ampicillin / Sulbactam in Comparison with Ceftriaxon for Pneunomia in a Medical ICU. Kibbel T 1, Süfke S 1, Fröhlich A 2, Dodt C 1, Djonlagic H 1 1 Internal Medicine I, Intensive Care Unit, University Clinic of Schleswig-Holstein, Campus Luebeck 2 Institute of Medical Biometry and Statistics, University of Luebeck. 249 Gender Specific Differences in Body Weight and QT Interval between Survivors and Nonsurvivors of Severe Bacterial Infections. Kibbel T, Süfke S, Dodt C, Djonlagic H Internal Medicine I, Intensive Care Unit, University Clinic of Schleswig-Holstein, Campus Luebeck. 250 Gender Specific Incidence and Mortality of Severe Bacterial Infections and Adjustment to Age and Normal Population. Kibbel T, Süfke S, Djonlagic H, Dodt C Internal Medicine I, Intensive Care Unit, University Clinic of Schleswig-Holstein, Campus Luebeck. 596 Multidrug-resistant Bacteria Isolated from Patients Hospitalized in the Intensive Care Units. WROBLEWSKA MM1, RUDNICKA J2, MARCHEL H2, LUCZAK M1,2 1Department of Medical Microbiology, Medical University of Warsaw, Poland; 2Microbiology Laboratory, Central Clinical Hospital, Medical University of Warsaw, Poland. 612 Cryptosporidiosis Treatment in Immunocompromised Host: a Still Open Question. 1Zardi EM, 1Picardi A, 1Afeltra A 1Interdisciplinary Center for Biomedical Research (CIR), Laboratory of Internal Medicine and Hepatology, University "Campus Bio-Medico", Rome, Italy. 329 Prospective study of empiric monotherapy with ceftazidime for low-risk grade IV febrile neutropenia after cytotoxic chemotherapy in cancer patients. Pnina Chernobelsky1, Konstantin Lavrenkov1, Klaris Riesenberg2, Samuel Ariad1, Doron Rimar2, Francisc Schlaeffer2, and Wilmosh Mermershtain1 Dept. of Oncology1 and Dept. of Internal Medicine E2, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel. 535 Antibiotic Selection Patterns in Acutely Febrile New Outpatients with or without Immediate Testing for C-Reactive Protein and Leukocyte Count. Takemura Y1,2, Ebisawa K2, Kakoi H2, Saitoh H2, Kure H2, Ishida H3, Kure M2 1National Defense Medical College, Tokorozawa, Japan; 2Nishi-Ohmiya Hospital, Saitama-City, Japan; 3Yamaguchi University School of Medicine, Ube, Japan. 398 Efficacy of Ceftazidime (CTZ) plus Clavulanic acid (CA) against ESBL Producing Gram-negative Bacteria (GNB). SUNITA MALHOTRA, T. MATHUR, S.SINGHAL, M. PANDYA, P.BHATEJA, T. BHADAURIYA, E.P.MADHVI RAO, SACHIN MALHOTRA, D.J.UPADHYAY, A.RATTAN Ranbaxy Research Laboratories, Gurgaon, Haryana, India. 484 Thalidomide in intractable intracranial tuberculosis: report of 4 children. SCHOEMAN JF1, FIEGGEN G2, SELLER N1, HARTZENBERG HB3 1Department of Paediatrics and Child Health and 2Department of Neurosurgery, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa; 3Department of Neurosurgery, Red Cross Children's Hospital, Cape Town, South Africa. 390 A Pharmacoeconomic Study of Antimicrobial Use for Surgical Prophylaxis on gastrectomy patients in a Tertiary Care Hospital. ONDA M1, ISE Y2, HAGIWARA K2, KAMEI M4, KATAYAMA S2, NISHIZAWA K2, HIRANO M2, KIYAMA T3 1Hiroshima International University, Hiroshima, Japan; 2Nippon Medical School Hospital, Tokyo, Japan; 3Nippon Medical School, Tokyo, Japan; 4Nihon University, Chiba, Japan. 448 Review of Clinical Studies with a Modern Combination of Amoxicillin (Ax) + Sulbactam (Sb) (AxS). LOPEZ H1; BANTAR C2; SOUTRIC J3; CARUSO N3; HEGUILEN R3; CASELLAS JM JR4; CASELLAS JM5; FARINATI A6; ARENOSO HJ3; RODRIGUEZ MD1 1Centro de Infectologia, Facultad de Medicina, Universidad de Buenos Aires; 2Hospital San Martin, Paraná, Argentina; 3Laboratorios Bago SA, Argentina; 4FUNCEI Argentina; 5CEA-Buenos Aires; 6Universidad del Salvador, Buenos Aires, Argentina. 280 Anthrax – Raising its Ugly Head in an Underdeveloped Country. DUTTA TK, KANUNGO R, GHOTEKAR LH Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India. 399 Double Blind Placebo controlled study to evaluate the efficacy of Oral Penicillin (OP) or Diethyl-carbamazine (DEC) or both (along with Foot hygiene) in the prevention of episodic Adenolymphangitis (ADL) in filarial lymphoedema. PANI SP1, YUVARAJ J1, VIJAYALAKSHMI N2, ELANGO A1, PAILY KP1, SAMBASIVA RAO R2 1Vector Control Research Centre (ICMR), Pondicherry, India; 2Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry, India. 379 Review On Human Toxoplasmosis: The Past, Present And Prospective Future. NISSAPATORN VEERANOOT1, QUEK KIA FATT2, MAHMUD ROHELA1, ABDULLAH KHAIRUL ANUAR1 1Department of Parasitology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. 2Department of Social and Preventive Medicine, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. 652 Dosing The Magic Bullets Against Intracellular Bacteria : Lessons From a Comparison between Beta-Lactams And Quinolones Against L. monocytogenes and S. aureus. M. BARCIA-MACAY, S. LEMAIRE, S. CARRYN, F. VAN BAMBEKE, M.P. MINGEOT-LECLERCQ and P.M. TULKENS Unité de Pharmacologie cellulaire et moléculaire, Université catholique de Louvain, Brussels – Belgium. 617 Relative Efficacy of Ciprofloxacin Dosing Regimens in the Treatment of Pseudomonas aeruginosa Infections. ZELENTISKY S1,2, ARIANO R1,2, HARDING GKM1,2, FORREST A3 1Univ. of Manitoba, Winnipeg, Canada; 2St. Boniface General Hosp., Winnipeg, Canada, 3SUNY Buffalo, Buffalo, USA. 207 Ten Years Experience with HACEK Infections – the Need to Standardize Antimicrobial Susceptibility Testing and to Develop Treatment Guidelines. HUI M 1, CHENG AFB 1 1 The Chinese University of Hong Kong, the Prince of Wales Hospital, Hong Kong SAR, China. 228 Therapeutic effect of 2-days vs. 3-days treatment of shigellosis with Ciprofloxacin in Albania. KALO T1 DAVACHI F2, NUSHI A1, BOJDANI R1, BEQO E1, PRIFTI S1, FEJZO E1, NOVI S1. 1Mother Theresa University Hospital Center, Tirana, Albania, 2New York Medical College, Valhalla, New York. Category: Antivirals - clinical studies 571 The Cost-Benefit of Therapy with Ganciclovir for Perinatal Cytomegalovirus Hepatitis. VANCÍKOVÁ Z Department of Paediatrics, University Hospital Motol, Prague, Czech Republic. 626 Relationship of Depression and Quality of Life in Interferon receiving Chronic Hepatitis Patients. Aytul Corapcioglu1, Sila Cetin Akhan2, Gulturk Koroglu1, Mine Ozkan3 1Kocaeli Universitesi Tip Fakultesi Psikiyatri AD. Sopali Kocaeli Turkiye 2Kocaeli Universitesi Tip Fakultesi Infeksiyon Hastaliklari ve Klinik Mikrobiyoloji AD. Sopali Kocaeli Turkiye 3Istanbul Universitesi Istanbul Tip Fakultesi Psikiyatri AD. Capa Istanbul Turkiye. 627 Alteration of Hb, platelet and PNL to Interferon-alpha in Chronic Hepatitis B With and Without Precore Mutant Strain. Sila Akhan, Emel Azakkaraali, Huseyin Uckardesler Kocaeli Universitesi Tip Fakultesi Infeksiyon Hastaliklari ve Klinik Bakteriyoloji AD. Sopali, Kocaeli 41900 Turkiye. 620 Clinical Pharmacokinetics of Adefovir Dipivoxil after Single and Multiple Oral Administration to Chinese Volunteers CHEN XY and ZHONG DF Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang, China. 176 Antiretroviral therapy as a model for determining the cost effectiveness of of anit-infective therapy. GRIMES RM, Helmy A University of Texas Houston Texas and Spoknae internal Medicne Residency Program, Spokane Washington, USA. 634 Three-Year Results of an In-Home Palivizumab Prophylaxis Program for the Prevention of Respiratory Syncytial Virus Infection. GOLOMBEK SG1, BERNING K1 and BERNING F1 1The Regional Neonatal Center, Westchester Medical Center/New York Medical College, Valhalla, New York, USA. Category: Antifungals - clinical studies 474 A Possible Treatment for Oral Candidosis or Pressure Sores, Using Anti-inflammatory Naphthoquinone derivatives with Antifungal Activity Isolated from Lithospermum erythrorhizon. SASAKI K1, Abe H2, Yoshizaki F1 1Tohoku Pharmaceutical University, Sendai, Japan; 2Senseki Hospital, Miyagi, Japan. 539 Fluconazole Prevents Multiple Organ Failure due to Septic Shock: an Experimental and Clinical Study. TARIQ M, JACOBS S, KHAN HA, EVANS DAP, AL MUSLIM O Armed Forces Hospital, Riyadh, Saudi Arabia. Category: Antimalarial compounds - clinical studies 116 The Plight of African children with Malaria. DAVACHI F1 1New York Medical College, Valhalla, New York. Category: Pharmacokinetics and tissue penetration of antiinfectives 492 Pharmacokinetic and average bioequivalence study of levofloxacin tablets in healthy Thai male volunteers. SERMSAPPASUK P, RUANGBANDIT T, POLNOK S, JIANMONGKOL P, INGKANINAN K, LOHITNAVY M 1Bioequivalence Test Center, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand 643 Clearance of Levofloxacin by Continuous-Veno-Venous-Hemodialysis (CVVHD): Influence of Dialyser Membrane and Dialysate Flow Rate – Implication for Dosing? SIEWERT S, DREWELOW B, MUELLER SC Institute of Clinical Pharmacology, Rostock, Germany. 653 Comparative bioavailability of two oral presentations of cefixime in healthy volunteers. SLANINKA-MICESKA M, LABACHEVSKI N, ZAFIROV D, JAKOVSKI K, KOSTOVA E, JOVANOSKA E Department of Preclinical and Clinical Pharmacology and Toxicology, Medical Faculty, Skopje, Republic of Macedonia. 579 Concentrations in Plasma and Urinary Excretion of Ciprofloxacin XR (1000 mg) versus Levofloxacin (500 mg) in Healthy Volunteers Receiving a Single Oral Dose. Florian M.E. Wagenlehner1, Uwe Tischmeyer1, Martina Kinzig-Schippers2, Christine Wagenlehner1, Fritz Sörgel2, Kurt G. Naber1 Department of Urology, St. Elisabeth Hospital, Straubing,1 and Institute for Biomedical and Pharmaceutical Research (IBMP), Nürnberg-Heroldsberg,2 Germany. 082 Pharmacokinetics and Pharmacodynamics of Subcutaneous Interferon Alpha-2b. BULITTA J1, FUHR U2, LANDERSDORFER C1, TOMALIK-SCHARTE D2, SZYMANSKI J2, KINZIG-SCHIPPERS M1, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg; 2Institute for Pharmacology, University of Köln, Köln, Germany. 213 Limitations in the Use of Drug Cocktails (DC) to Compare the Pharmacokinetics (PK) of Drugs: Ciprofloxacin (CIP) vs. Levofloxacin (LEV). NABER KG2, BULITTA J1, JAKOB V1, KINZIG-SCHIPPERS M1, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg; 2Urology Clinic, Straubing, Germany. 081 Self-Inhibition of Clarithromycin's (CLA) Metabolism in Humans at Steady-state. BULITTA J1, HORKOVICS-KOVATS S2, BOREK M2, HÜTTNER S1, KINZIG-SCHIPPERS M1, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg, Germany; 2Sandoz, Kundl, Austria. 214 High Sensitivity LC-MS/MS Analysis to Assess Phenotyping of a Drug Cocktail. KINZIG-SCHIPPERS M, JAKOB V, RODAMER M, SKOTT A, SÖRGEL F Institute for Biomedical and Pharmaceutical Research, Nürnberg, Germany. 331 Pharmacokinetic profile of danofloxacin (DAF) 18% solution in plasma, milk and tissues after subcutaneous (SC) injection in dairy cows. MESTORINO N, PESOA J, LUCAS M, ERRECALDE J. Department of Pharmacology, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata. 005 PHARMACOKINETICS OF IMIPENEM IN SHEEP WITH SPECIAL REFERENCES TO IT'S HEPATO-RENAL EFFECTS. ABO EL-SOOUD K1, KHAMMAS W2, NADIR KADRI M2 1Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Egypt 2Dept. of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Jordan. 242 Comparison of the Pharmacokinetics of Piperacillin and Sulbactam during Intermittent and Continuous Intravenous Administration. J LANGGARTNER1, N LEHN2, T GLÜCK1, H HERZIG1, F KEES3 1Department of Internal Medicine I, 2Institute of Medical Microbiology and Hygiene and 3Dept. of Pharmacology, University of Regensburg, Regensburg, Germany. 255 Plasma Concentrations, Urinary Excretion and Bactericidal Activity of Linezolid (LIN) (600mg) versus Ciprofloxacin (CIP) (500mg) in Healthy Volunteers After a Single Oral Dose. WAGENLEHNER F1, NABER KG1, KINZIG-SCHIPPERS M2, BULITTA J2, SÖRGEL F2 1Urology Clinic, Straubing; 2Institute for Biomedical and Pharmaceutical Research, Nürnberg, Germany. 493 Development of a levofloxacin pharmacokinetic model: Simulations in different populations, different dosing regimens and in AIDS and critically ill patients. SERMSAPPASUK P.1,2 , LOHITNAVY M.1,2 1 Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand 2Bioequivalence Test Center, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand. 375 Population Pharmacokinetics (PopPK) of Continuous (CI) and Intermittent Infusion (II) Piperacillin/Tazobactam (TZP) in Patients with Complicated Intra-abdominal Infection (IAI). C. Li1, J.L. Kuti1, C.H. Nightingale1, D.L. Mansfield2, A. Dana2, D.P. Nicolau1 1 Ctr. for Anti-Infective Res. and Dev., Hartford Hosp., Hartford, CT 2 Wyeth Pharma., Collegeville, PA. 622 Multicompartment Pharmacokinetic Models with Enterohepatic Circulation (EHC) and Remetabolization (RM). ZLATOŠ P1, HORKOVICS-KOVATS S2 1Comenius University, Bratislava, Slovakia, 2Sandoz GmbH, Kundl, Austria. 029 Pharmacokinetic simulation of two formulations of amphotericin-B. ARIANO RE 1,2, ZELENITSKY SA 1,2 1 Department of Pharmacy, St. Boniface General Hospital, and 2 Faculties of Pharmacy and Medicine, University of Manitoba, Winnipeg, MB, Canada. 576 Pharmacokinetics and Antileishmanial Activity of Piperine Encapsulated in Lipid Nanospheres. VOBALABOINA V1, VEERAREDDY PR1, AND ALI N2. 1.University College of Pharmaceutical Sciences, Kakatiya University, Waranga, A.P-INDIA. 2. Indian Institute of Chemical Biology,Jadavpur, Kolkata, INDIA. 488 Pharmacokinetics of a Single and Multiple Doses of Ertapenem in Patients with End-Stage Renal Disease. SCHÜTZE LM1*, MITCHELL A1*, BÜHRMANN S1, KAEVER V2, PHILIPP Th1, SCHÄFERS RF3, WENZEL RR4, SCHNEEMANN H1 1Essen University Hospital, Essen, Germany; 2Medical School Hannover, Hannover, Germany; 3KfH Kidney Centre Essen, Essen, Germany; 4Clinic of Internal Medicine, Zell am See, Austria 241 Comparison of the Pharmacokinetics of Meropenem during Intermittent and Continuous Intravenous Application in Patients with Renal Failure Treated by Continuous Renal Replacement Therapy. J LANGGARTNER1, T GLÜCK1, M RENG1, F KEES2 1Department of Internal Medicine I, 2Dept. of Pharmacology, University of Regensburg, Regensburg, Germany. 068 Usefulness of Cutaneous Microdialysis to Evaluate Ciprofloxacin and its Desethylene Metabolite into Skin After Oral Administration of the Parent Drug. BIELECKA-GRZELA S., KLIMOWICZ A. Dermatopharmacotherapy Division, Department of Dermatology and Venereology, Pomeranian Medical University, Szczecin, Poland. 478 Human Microdialysis: Urea as an Endogenous Reference Compound to Determine Relative Recovery of Drugs. SCHWALBE O1,2, BUERGER C1, PLOCK N1, SCHEERANS C1, KLOFT C1 1Freie Universitaet Berlin, Institute of Pharmacy, Berlin, Germany; 2Universitaet Bonn, Bonn, Germany. 416 Special Characteristics of Microdialysis with Vancomycin – pH Dependence of Microdialysis Recovery. PLOCK N, KLOFT C Freie Universitaet Berlin, Institute of Pharmacy, Berlin, Germany. 417 Tissue Pharmacokinetics of Linezolid Assessed by Microdialysis. BUERGER C1, PLOCK N1, JOUKHADAR C2, MUELLER M2, KLOFT C1 1Freie Universitaet Berlin, Institute of Pharmacy, Berlin, Germany; 2University School of Medicine, Vienna, Austria. 090 Tissue Penetration, Pharmacokinetic and Pharmacodynamic Profile of Linezolid, a Novel Oxazolidinone Antibiotic for the Treatment of Serious Gram-Positive Infections – A Review. CHATTOPADHYAY B1, ALI S2 1Department of Medical Microbiology and 2Department of Pharmacy, North Middlesex University Hospital, London, United Kingdom. 583 The Effect of Liposomal Surface Charge on the Disposition of Liposome-Encapsulated Gentamicin to the Rat Liver, Brain, Lungs and Kidneys after Intraperitoneal Administration. A. ABRAHAM AND A. WALUBO Department of Pharmacology, University of the Free State, South Africa. 529 Tissue and Serum Concentrations of Levofloxacin 500 mg Administered Intravenously or Orally for Antibiotic Prophylaxis in Biliary Surgery. SWOBODA S1, OBERDORFER K1, KLEE F2, GEISS HK1, HOPPE-TICHY T1 1University of Heidelberg, Germany; 2Salem Hospital, Heidelberg, Germany. 446 Tissue Penetration of Cefditoren (CEE) into Bronchial Mucosa (BM) and Epithelial Lining Fluid (ELF) in Patients Undergoing Fiberoptic Bronchoscopy. RODAMER M1, LANDERSDORFER C1, JAKOB V1, SKOTT A1, HINDER M2, KINZIG-SCHIPPERS M1, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg; 2Grünenthal GmbH, Aachen, Germany. 288 Determination of Moxifloxacin in Bone by HPLC-FLUO. LANDERSDORFER C1, SKOTT A1, KINZIG-SCHIPPERS M1, HOLZGRABE U2, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg; 2Institut für Pharmazie und Lebensmittelchemie, University of Würzburg, Würzburg, Germany. 043 Pharmacokinetic Studies of Fluconazole in Cerebrospinal Fluid (CSF) in Children with Hydrocephalus Using Solid-Phase Extraction (SPE) and High-Performance Liquid Chromatography (HPLC). BAFELTOWSKA JJ1, BUSZMAN E1 1Medical University of Silesia, School of Pharmacy, Katowice, Poland. 050 Population Pharmacokinetics of Gentamicin in Neonates. BARCIA E1, GARCIA B2, PEREZ F2, MOLINA IT1 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain; 2 Hospital Severo Ochoa, Madrid, Spain. 447 Personalized Isoniazid (INH) Dosing Based on Genotyping for Arylamine N-Acetyltransferase Type 2 (NAT2). RODAMER M1, FUHR U2, TOMALIK-SCHARTE D2, JETTER A2, BULITTA J1, KINZIG-SCHIPPERS M1, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg; 2Inst. of Pharmacology, Univ. of Köln, Köln, Germany. 517 Dosing of Antiinfectives - "ONE SIZE FITS ALL" vs. Individualized Therapy. SÖRGEL F, BULITTA J, KINZIG-SCHIPPERS M, HÜTTNER S Institute for Biomedical and Pharmaceutical Research, Nürnberg, Germany. 268 Therapeutic drug monitoring of Aminoglycoside Antibiotics – Retrospective Study. KOMZAKOVA I, BROZMANOVA H, KORISTKOVA B, KACIROVA I, GRUNDMANN M Department of Clinical Pharmacology, University Hospital and Medico-Social Faculty, University of Ostrava, Ostrava, Czech Republic. 352 Treatment Strategy for MRSA Infection in Critically Ill Patients Using Therapeutic Drug Monitoring (TDM): Our Experience in Japan. MORIWAKI Y1, SUGIYAMA M1, SUZUKI J1, ARATA S1, TAHARA Y1, TOYAMA H1, IWASHITA M1, FUKUYAMA H1, NAKAMURA K1, SHIMOYAMA T1, MATSUZAKI S1, AMANO S1, SUZUKI N1 1Critical Care and Emergency Center, Yokohama City University Medical Center, Yokohama, Japan. 360 Amphotericin B Dosing Guidelines and Target Steady State Trough Concentrations in Children with Malignant Diseases. NATH CE1,2,3, MCLACHLAN AJ3, SHAW PJ2, COAKLEY JC1 AND EARL JW1 Departments of Biochemistry1 and Oncology2, The Childrens Hospital at Westmead, NSW, Australia; 3Faculty of Pharmacy, University of Sydney, NSW, Australia. Category: Pharmacodynamics and experimental therapy of antiinfectives 063 Pharmacodynamics of Antibiotics in the Respiratory tree. E Bergogne-Berezin Bichat University, Masson, France. 449 Review of Pharmacodynamic/Pharmacokinetic (PD/PK) Studies with a Modern Combination of Amoxicillin (Ax) + Sulbactam (Sb) (AxS). LOPEZ H1; BANTAR C2; SOUTRIC J3; CARUSO N3; HEGUILEN R3; CASELLAS JM JR4; CASELLAS JM5; FARINATI A6; ARENOSO HJ3; RODRIGUEZ MD1 1Centro de Infectologia, Facultad de Medicina, Universidad de Buenos Aires; 2Hospital San Martin, Paraná, Argentina; 3Laboratorios Bago SA, Argentina; 4FUNCEI Argentina; 5CEA-Buenos Aires; 6Universidad del Salvador, Buenos Aires, Argentina. 473 Comparative studies on pulse and continuous oral norfloxacin treatment in broilers and turkeys. Géza Sárközy Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, Budapest, Hungary. 628 Identification of potential markers of microfilaremia in Mandrillus sphinx/Loa model of infection. AKUE JP , BLAMPAIN AZZIBROUCK G, MBOU MOUTSIMBI R; MOUKANA H Filarial research unit, Centre International de Recherche Médicales de Franceville ( CIRMF), Gabon. 616 Peritoneal Fluid Inhibitory Titre (PFIT) Test to Compare Antibiotic Regimens for Peritonitis. ZELENTISKY S1,2, STRIJACK C1, ARIANO R1,2, KLER K1, HARDING GKM1,2 1Univ. of Manitoba, Winnipeg, Canada; 2St. Boniface General Hosp., Winnipeg, Canada. 055 Bactericidal activity of oral antibiotics in ex vivo model. BEDENIC B1, TOPIC M2 1»A. Stampar» School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia 2student-Biotechnology Faculty, Zagreb, Croatia. 629 The Killing of Multidrug Resistant Streptococcus pneumoniae (MDRSP) by Gatifloxacin (GA), Gemifloxacin (GM), Levofloxacin (Lfx) and Moxifloxacin (Mfx) Over a Range of Bacterial Inoculums Using 2 Different Drug Concentrations. BLONDEAU JM1,2, BORSOS S1, HESJE C2, BLONDEAU LD1 1Royal University Hospital, Saskatoon, SK, Canada, 2University of Saskatchewan, Saskatoon, Canada. 649 Targeted Novel Therapeutics for Dental Biofilms. GAFFAR A1, BOYD T1, SREENIVASAN P1 1Colgate-Palmolive Corporate Technology Center, Piscataway, New Jersey, USA. 252 Oral Administration of Clarithromycin (CAM), a Macrolide Antibiotic of Erythromycin, Stimulates Mucosal Immunoresponse and Elevates IgA Levels in the Airway of Mice after Infection with Influenza A Virus (IAV). IDE K, MIZUNO D, ICHINOMIYA T, KIDO H Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan. 309 Determination of PK/PD Parameters Correlating With In Vivo Efficacy of RBx 7644 In Neutropenic Murine Thigh Infection Model. SUNITA MALHOTRA, T. BHADAURIYA, E.P.MADHVI RAO, SONALI KAKKAR, J.K.PALIWAL A.RATTAN Ranbaxy Research Laboratories, Gurgaon, Haryana, India. 410 Anticryptosporidial Activity of Mangiferin in Neonatal Mice Experimentally Infected with Cryptosporidium Parvum. PERRUCCI S1, FICHI G1, BUGGIANI C1, ROSSI G2, FLAMINI G3, MORELLI I3 1Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti-University of Pisa, Italy 2Dipartimento di Scienze Veterinarie- Università di Camerino, Italy 3Dipartimento di Chimica Bioorganica e Biofarmacia-University of Pisa, Italy. 361 Clindamycin Is Neuroprotective in Experimental Streptococcus pneumoniae Meningitis Compared to Ceftriaxone. BÖTTCHER T1/2, REN H3, GOINY M4, GERBER J2, LYKKESFELDT J5, KUHNT U6, LOTZ M2, BUNKOWSKI S2, WERNER C2, SCHAU I2, SPREER A2, CHRISTEN S3, NAU R2 1University of Rostock, Rostock, Germany; 2Georg-August-University, Göttingen, Germany; 3University of Bern, Bern, Switzerland; 4Karolinska Institute, Stockholm, Sweden; 5Royal Veterinary University, Copenhagen, Denmark; 6Max- Planck-Institute of Biophysical Chemistry, Göttingen, Germany. 317 Combined Immunomodulating Effects of BCG and Lentinan after Intranasal Application in Guinea Pigs. DRANDARSKA I1, KUSSOVSKI V2, NIKOLAEVA S1, MARKOVA N2 1 NCIPD, Sofia, Bulgaria 2 Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. 538 Complete Remission after Treatment of Chronic Fatigue Syndrome (CFS) in 118 Falcons using Potassium Arsenite 0.05%. TARELLO W1 1International Veterinary Hospital, Ahmadi, Kuwait. 537 Successful Thiacetarsamide Sodium Therapy against Coagulase-Negative Staphylococcus spp. Bacteraemia in 3 Amazon Parrots Diagnosed with Chronic Fatigue Syndrome (CFS). TARELLO W1 1International Veterinary Hospital, Ahmadi, Kuwait. Category: Microbiology 187 Bacterial Susceptibility to Antibiotics in Wildlife in Iran. Hemmatzadeh F1 1 Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. 198 Effects of Mupirocin at Subinhibitory Concentrations on Biofilm Formation in Pseudomonas aeruginosa. HORII T, Morita M, Ishikawa J, Takeshita A, Maekawa M Hamamatsu University School of Medicine, Hamamatsu, Japan. 219 Antimicrobial Activity of Ciprofoxacin Against Nosocomial Infection Bacteria. ABSS ALI JAVADI, MOHAMMAD JALALI, SINA MOBASHERI, ALI FARZAM Isfahan University of Medical Sciences. 597 Epidemiology and Antibiotic Susceptibility of Strictly Anaerobic Bacteria Isolated from Patients Hospitalized in a Tertiary Care Hospital. WROBLEWSKA MM, KOT K, ROKOSZ A, SAWICKA-GRZELAK A, LUCZAK M Department of Medical Microbiology, Medical University of Warsaw, Poland. 003 Experimental Studies on Synergism between Nitrofurantoin and Piperitone by Checkerboard Titer Test. ABDOLPOOR F1, SHAHVERDI AR1, FAZELI MR1, JAMALIFAR, H1, RAFII F2 1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran Medical Sciences University, Tehran Iran; 2 Division of Microbiology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR, USA. 148 Susceptibilities of UrinaryTract Isolates of Extended-Spectrum (ESBL) and AmpC-Type (AmpC) ß-Lactamase-Producing Escherichia coli (E. coli) against Six First-line Oral Antibiotics Commonly Used for Community-Acquired Urinary Tract Infections (UTIs). FARHAT SE1, BROWN S2, NOORPOUR L1, JAMIESON F2, SIMOR AE1,3,4 1Alpha Laboratories Inc., Toronto, ON, Canada; 2Public Health Laboratory, Ministry of Health and Long-Term Care, Toronto, ON, Canada; 3Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada; 4University of Toronto, Toronto, ON, Canada. 323 Antimicrobial activities of various antimicrobials against various types of Extended-spectrum ß-lactamase (ESBL) in Escherichia coli in Japan. MATSUMOTO T, MURATANI T, YAMADA Y, and TAKAHASHI K University of Occupational and Environmental Health, Kitakyushu, Japan. 012 Extended-Spectrum Beta-Lactamases in Teaching Hospitals in Nigeria. AIBINU IE1, 2, ODUGBEMI TO2, ADEYEBA JP1 and MEE BJ3 1Ladoke Akintola University of Technology, Ogbomoso, Nigeria; 2College of Medicine, University of Lagos, Nigeria; 3The University of Western Australia, Australia. 016 Susceptibility of Different MRSA Clones to Metals and Biocides. Al-DOORI Z1, D MORRISON1, G EDWARDS1 and C GEMMELL2 1Scottish MRSA Reference Laboratory , Department of Microbiology, Stobhill Hospital, Glasgow, Scotland, UK. & 2Glasgow University Department of Bacteriology, Glasgow. 395 Time-series Analysis Based on Genotyping and Antibiotic Susceptibility for Methicillin-Resistant Staphylococcus aureus (MRSA) Infection in a University Teaching Hospital. K. Osawa1, 2, T. Chida2, N. Okamura2 1Kobe University School of Medicine, Kobe, Japan; 2 Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 436 Comparison between molecular epidemiology, geographical region and drug resistance in Mycobacterium tuberculosis strain isolated from Iranian and Afghan patients. RASHID RAMAZANZADEHa,b, PARISSA FARNIAa, NOUR AMIR MOZAFARIb , ZEINAB GHADER TOYONCHIa, JABER KAMRANa, FROUZAN MOHAMMMADIa, MEHDI MIRSAEDIa, MOHAMMAD REZA MASJEDIa aNational Research Institute of Tuberculosis and Lung Disease (NRILTD) Shaheed Beheshti University of Medical Sciences, Tehran, Iran bMicrobiology Department of Iran University of Medical Science, Tehran, Iran. 536 Drug susceptibility test of Mycobacterium tuberculosis clinical isolates by simple fibroblast assay. TAKII T 1, HAMASAKI S2, HIRANO K2, ABE C 2, ONOZAKI K 1 1Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan, 2Research Institute of Tuberculosis, JATA, Kiyose, Tokyo, Japan. 351A Inhibition of Treponema enzymes with Salvarsan and derivatives. Morgan HW1, Ronimus, RS1, Lloyd, N2, Nicholson, B K2 1Dept of Biological Sciences,2Dept of Chemistry, University of Waikato, Hamilton, New Zealand. 497 Studies on Antimicrobial Activities of Berberis aristata DC., a Medicinal Plant Species of the Himalayas and Nilgiris Hills in India. SHAHID M1, MALIK A1, SHAHZAD A2, RAHEEM T3, FATIMA T3, TAJUDDIN M3, LATIF A3 & ANIS M2 1Microbiology Laboratory, Jawaharlal Nehru Medical College & Hospital, Aligarh Muslim University Aligarh, India; 2Biotecnology Unit, AMU Aligarh, India; 3 Faculty of Unani Medicine, AMU Aligarh, India. Category: Adverse events, interactions and toxicity of antiinfectives 530 Cutaneous Adverse Effects after Terbinafine Intake. SZEPIETOWSKI JC Department of Dermatology, Venereology and Allergology, University of Medicine, Wroclaw, Poland. 290 Respiratory Responses to Central Penicillin Microinjection in the Medullar Structures of the Rat. LEBEDEVA M A Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. 659 Protection of Inner Ear Sensory Hair Cells from Aminoglycoside Toxicity by Serofendic Acid. NAKAGAWA T1, KITA T1, KIM TS1, IWAI K1, TAKEBAYASHI S1, HIGASHI T1, AKAIKE A2, ITO J1 1Kyoto University Graduate School of Medicine and 2Graduate School of Pharmaceutical Science, Kyoto, Japan. 556 Summer Flounder (Paralichtys dentatus) Cytochrome P450 Responses to Combination Ormetoprim-Sulfadimetoxine Treatment. TOPIC POPOVIC N1, BABISH JG2, BOWSER PR3 1Rudjer Boskovic Institute, Zagreb, Croatia; 2Ashni Proteomics, Ithaca, NY, USA; 3Cornell University, Ithaca, NY, USA. Category: Mechanisms of pharmacological and biochemical action of antiinfectives 351 Review: Anti-inflammatory effects of fosfomycin. MORIKAWA K1, NONAKA M1, YOSHIKAWA Y1, TORII I2 1Depatment of Nutrition, Sagami Women's University, 2Department of Pathology, School of Medicine, Shimane University. 424 Drug resistance to ABC transporter blockers modulates glucose transport in Leishmania. Machuca, C. 2, Rodríguez, A. 2, Herrera, M. 2 and Ponte-Sucre, A1,2 1Institut für Molekulare Infektionsbiologie, Universität Würzburg, Germany 2Laboratorio de Fisiología Molecular, IME, Universidad Central de Venezuela. 006 How Leishmania (Leishmania) amazonensis Reaches Central Nervous System? ABREU-SILVA, AL1/2 AND CALABRESE, KS2 1Universidade Estadual do Maranhão, São Luís – Maranhão Brazil 2Laboratório de Imunomodulação (DP) do Instituto Oswaldo Cruz, Rio de Janeiro, Brazil. 147 Structure Genomic of Pathogenic Protozoa. Erkang Fan Biomolecular Structure Center, Department of Biochemistry, University of Washington, Seattle, WA, USA. 381 Participation of the inhibition of the MexAB-OprM transporter in expression of the quorum-sensing system in Pseudomonas aeruginosa. NOMURA N1, SAWADA I1, MASEDA H1, NAKAE T2, UCHIYAMA H1 1University of Tsukuba, Tsukuba, Japan; 2Tokai University School of Medicine, Isehara, Japan. 465 A New Interpretation on the Intestinal Transport of Bacampicillin and Its Inhibitory Effect on P-Glycoprotein. SAITOH H Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan. 114 Dependency of Aminoglycoside 3'-Phosphotransferase (APH) VIII Activity and Antibiotic Resistance on Protein Serine/Threonine Kinases (Ser/Thr-PKs) in Actinomycetates. DANILENKO VN, ELIZAROV SM, SIZOVA IA, ALEKSEEVA MG The State Research Institute for Biotechnology of Protein Biosynthesis, Moscow, Russia. 115 Cell Energy State and Drug Dose Effects on the Efficiency of Polycationic Antibacterials. DAUGELAVICIUS R Department of Biochemistry and Biophysics, Vilnius University, Lithuania. 320 Effect of Antimicrobial Agents on the Expression of E. coli 0157:H7 Genes Encoding the Shiga-like Toxins. Ghassan M. Matar*, Elias Rahal. and Ali Kanbar Department of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. 369 The Application of Raman Spectroscopy for the Investigation of the Impact of Antiinfective Agents. NEUGEBAUER U1, HOLZGRABE U2, POPP J1, 1Institut of Physical Chemistry, FSU Jena, Jena, Germany 2Institute of Pharmacy, University of Würzburg, Am Hubland, Würzburg, Germany. 380 p38 MAPK Associates Stereoselective Priming by Grepafloxacin on Superoxide Production in Human Neutrophils. NIWA M1,2, HIROTA M4, KOZAWA O2, AND FUJIMOTO S3 1Medical Education Development Center and Department of 2Pharmacology, Gifu University School of Medicine, Gifu, Japan, 3Department of Environmental Biochemistry, Kyoto pharmaceutical University, Kyoto, Japan, and 4Department of Drug Metabolism, Drug Safety Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Japan. 564 Effect of Fluoroquinolones on Gene Expression of Endothelial Cells Stimulated with Tumor Necrosis Factor-a. URIARTE SM1, MOLESTINA RE1, MILLER RD1, RAMIREZ JA1, SUMMERSGILL JT1. 1University of Louisville School of Medicine, Louisville, KY, USA. Category: In vitro action of antimalarials 026 Antimalarial Activity of Malaysian Plasmodium falciparum Clones after Three Years of Continuous In Vitro Culture. ANG HH1, CHEANG HS1, MAK JW2 1School of Pharmaceutical Sciences, University Science Malaysia, Penang, Malaysia; 2Institute for Medical Research, Kuala Lumpur, Malaysia. 062 Antimalarial activities of Trioxaquines?, new modular molecules generation. BENOIT-VICAL F1, 2 , DECHY-CABARET O1, ROBERT A1, LOUP C1, BERRY A2, MAGNAVAL JF2, SEGUELA JP2, MEUNIER B1 1Laboratoire de Chimie de Coordination du CNRS, Toulouse, France ; 2Service de Parasitologie - Mycologie, Rangueil University Hospital, Toulouse, France. 136 Chloroquine Accumulation Properties of Plasma Membranes Vesicles Isolated from the Malarial Parasite, Plasmodium falciparum. ELANDALLOUSSI LM1, SMITH PJ2 1CCMar, Universidade do Algarve, Portugal; 2Groote Schuur Hospital, University of Cape Town, South Africa. 601 Functional and Genetic Analysis of the Human Inducible Nitric Oxide Synthase Promoter and Its Predisposition to Malaria. WEIMING XU & LIZHI LIU Wolfson Institute for Biomedical Research, University College London. Category: Antiviral agents 531 Potential for immunostimulaion of Cytokine Response in Hepatitis Chronic B. SZKARADKIEWICZ A, JOPEK A, WYSOCKI J Poznan University of Medical Sciences, Poznan, Poland. 165 The Effects of Genom Mutations in HCV-1b on IFN sensitivity in Hungarian Patients. GERVAIN J1, SIMON J2, CZIBULA A3, KALMAR T3 1Szent Gyorgy County Hospital, Szekesfehervar, Hungary 2 University of Oxford, UK 3 Biological Research Centre, Szeged, Hungary. 262 The Human CD81 Receptor as Target for the Development of Anti-HCV Drugs: Computer-Aided Search for Ligands and Preliminary Experimental Results. KLEIN CD1, HARTMANN RW1, HOLZER M1, KRONENBERGER B2, NEUGEBAUER A1, ZEUZEM S2 1FR 8.2 Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany. 2Klinik für Innere Medizin II, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany. 196 Impact of Erythrocyte Ribavirin Concentration in Hemoglobin Reduction induced by Interferon and Ribavirin Combination Therapy. HOMMA M1, INOUE Y2, HOSONO H2, MATSUZAKI Y1, TANAKA N1, SHIBATA M3, MITAMURA K3, HASEGAWA Y1, NAGASAWA T1, KOHDA Y1 1University of Tsukuba, Ibaraki, Japan; 2Tsukuba University Hospital, Ibaraki, Japan; 3Showa University, Tokyo, Japan. 354 Hepatitis C Virus (HCV) pseudoparticles as a powerful tool to develop new HCV entry inhibitors. KIRCHHOFF F1, STÄNDKER L2, MÜNCH J1 1Department of Virology, University of Ulm, Ulm; 2IPF Pharmaceuticals, Hannover. 391 Antiviral Potential of Soluble Form of Herpesvirus Entry Mediators to Alphaherpesvirus Infection. ONO E1, AMAGAI K1,2, TAHARAGUCHI S1, TOMIOKA Y1, WATANABE Y1,2, YOSHINO S1,3, CHEREL P4, UEDE T1 1Hokkaido University, Sapporo, Japan; 2Sankyo Labo Service Corporation, Tokyo, Japan; 3Gene Techno Science, Sapporo, Japan; 4France Hybrids, St Jean De Braye, France. 123 Antipicornavirus Activity of Synthetic Flavanoids and Flavonoids. DESIDERI N1, QUAGLIA MG1, CONTI C2 1Dipartimento di Studi Farmaceutici, 2Dipartimento di Scienze di Sanità Pubblica, Università "La Sapienza", Roma, Italy. 040 MDR1 P-gp Activity In Intact Human Placental Tissue; Up- regulation by Retroviral Transduction. DIANE E. ATKINSON1, COLIN P. SIBLEY1 , LESLIE J. FAIRBAIRN2 AND SUSAN L. GREENWOOD1 1University of Manchester, Manchester England 2Paterson Institute of Cancer Research, Manchester England. 032 THEORETICAL INVESTIGATION OF THE TRIPHOSPHATE FORMS OF AZIDOTHYMIDINE AND THYMIDINE. M. Arissawa1*, J. Felcman1 and J. O. Machucca Herrera2 1 Departamento de Química, Pontifícia Universidade Católica do Rio de Janeiro – Rua Marquês de São Vicente 225, Gávea, Rio de Janeiro, Brazil 2 Departamento de Química Inorgânica, Universidade Federal do Estado do Rio de Janeiro – Ilha do Fundão, Rio de Janeiro, Brazil. 058 Negatively charged albumins are fusion inhibitors in HIV infection and can be used as therapeutically active carriers for other anti-HIV. BELJAARS L, POELSTRA K, MEIJER DKF. Dept. Of Pharmacokinetics and Drug Delivery, GUIDE, University of Groningen, Groningen, The Netherlands. 192 A Novel pH Responsive Lipid-Drug Nanoparticle Composed of an HIV Protease Inhibitor, Indinavir, Enhanced Drug Localization and Viral Load Reduction In Lymphoid Tissues: A Proof of Concept Study in HIV-2287-Infected Macaques (new data). KINMAN L, BRODIE SJ, TSAI CC, BUI T, LARSEN K, SCHMIDT A, ANDERSON D, MORTON WR, HU SL, HO RJY University of Washington, Seattle, WA, USA. 506 A Rapid and Low-Cost Microfluidic Device for Monitoring Disease Progression in Response to Drug Therapy. SIA SK, LINDER V, SIEGEL A, NAROVLYANSKY M, PARVIZ BA, WHITESIDES GM Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA (USA). 034 SARS Coronavirus E Protein Forms a Highly Unusual Palindromic Transmembrane Helical Hairpin that Explains its Role in Viral Budding. ARBELY E1, KHATTARI Z2, BROTONS G2, SALDITT T2, ARKIN IT1 1Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel; 2Institut für Röntgenphysik, Georg-August-Universität, Göttingen, Germany. 577 Salvarsan then – Sialidase Inhibitors now –both Chemotherapeutics. VOGEL GE, BLASINI R, HECKLER R, HOFSCHNEIDER P.H, KLENK H.D, KOMM CH, PRAGER J, SCHÄFER B, SCHAUER R, SCHÖTTLER M, SCHOTTDORF B, VASOLD M, WUTZLER P Category: Resistance to antiinfectives 069 Monitoring of Antimicrobial Resistance among Bacteraemic Clinical Isolates in Slovakia. BLAHOVA J., KRALIKOVA K., KRCMERY V. SR., BABALOVA M. Slovak Medical University, Bratislava, Slovakia. 073 Catheter-Associated Urinary Tract Infections : Prevalence of Uropathogens and Patterns of Antimicrobial Resistance in an Italian Hospital (1996-2003). Bonadio M., Pichierri G., Costarelli S., Tanzilli P., Morelli P., Mori S., Tagliaferri E. Section of Infectious Diseases, University of Pisa. 096 Present status of drug resistance for conventional and newer drugs among gram negative bacilli isolated from hospitalized patients in central India. Chitnis S, Chitnis V, Hemwani N and Chitnis DS. Medical University of Bialystok, Poland. 145 Standard Treatment Guidelines and Antibiotic Resistance in South Africa. ESSACK, SY1, CONNOLLY C, 2 STURM, A.W.1 University of KwaZulu-Natal, 2Medical Research Council, Durban, South Africa. 150 Molecular Mechanism of Resistance to Ampicillin among Isolates of Enterococcus faecium Recovered from Patients in Tehran, Iran. FEIZABADI MM1, SHAYEGH MM 1, ASADI S2, GHARAVI S1 and ALIABADI K3 1Alzahra University1, Tehran, Iran; 2Labbafinejad Hospital2 Tehran, Iran; 3National Research Center for Genetic Enginerring and Biotechnology, Tehran, Iran. 158 The Spread of Metallo-?-Lactamase producing Pseudomonas aeruginosa in Japanese Small Hospitals. SHIGERU FUJIMURA1, TOSHIO SATO2, KEIKO SHIRAHATA2, YOSHIHISA NAKANO1, YUTAKA TOKUE3, AKIRA WATANABE3. 1 Department of Microbiology, Miyagi University, Miyagi pref., Japan; 2 Japan Microbiology Laboratories, Sendai, Japan; 3 Institute Development Aging and Cancer, Tohoku University, Sendai, Japan. 234 Typhoid Fever in Africa: Emerging Flouroquinolone Resistance. S KARIUKI1,3, G REVATHI2, J MUYODI1, J MWITURIA1, A MUNYALO1, S MIRZA3, CA HART3 1Centre for Microbiology Research, KEMRI, Kenya, 2Department of Medical Microbiology, Kenyatta National Hospital, Kenya, 3Department of Medical Microbiology and Genito-Urinary Medicine, Liverpool, UK. 651 Cellular Pharmacokinetics of Quinolones Revisited : Role of the MDR Efflux Pumps Expressed in Macrophages. J.M. MICHOT, M. HEREMANS, F. VAN BAMBEKE, M.P. MINGEOT-LECLERCQ and P.M. TULKENS. Unité de Pharmacologie cellulaire et moléculaire, Université catholique de Louvain, Brussels – Belgium. 263 Distribution of Aminoglycoside Resistance Genes in Recent Clinical Isolates of Enterococci in Japan. KOBAYASHI N1, ALAM M1, ISHINO M1, MISE K1, SUMI A1, UEHARA N2, WATANABE N2 1Sapporo Medical University School of Medicine, Sapporo, Japan; 2Sapporo Medical University Hospital, Sapporo, Japan. 496 Study of multi drug resistance in Serrstia marcescene and cloning of responsible genes. SHAHCHERAGHI FRESHTEH (PhD)1, TSUCHIYA TOMFUSA(PhD)2 1-Department of Bacteriology, Pasteur Institute of Iran, IR, Iran 2- Faculty of pharmaceutical science- Okayama University Japan 585 Antibiotic and Antimicrobial Resistance, and Efficiency Disruption by Teas and Nutraceuticals. PL WARD, M DONNELLY, A FRANKLIN, J HONG SE KATZ Cook College, NJAES, Rutgers, the State University of New Jersey,New Brunswick, NJ, USA. 161 Analysis of the Plasmid that Can Transfer Antibiotic Resistance Genes from Fish Farm Bacteria to Clinical Bacteria. FURUSHITA M1, 2, MAEDA T1, AKAGI H1, OHTA M2, SHIBA T1 1Department of Food Science and Technology, National Fisheries University, Shimonoseki, Japan; 2Graduate School of Medicine, Nagoya University, Nagoya, Japan. 036 Presence of Virulence genes and Antimicrobial resistance in Shiga toxin producing E.coli(STEC) and Enteropathogenic E.coli (EPEC). Mohammad Mehdi Aslani , F .Shoraj, J . Rehisi Microbiology Dept., Institute Pasteur of Iran 501 ANTIMICROBIAL RESISTANCE AND CLASS 1 INTEGRONS in Escherichia coli ISOLATED from Human and WATER SOURCES. SHEHABI AA1, ODEH FJ1, FAYYAD M2 1Department of Pathology-Microbiology, Faculty of Medicine, 2Water Research Center2,University of Jordan, Amman and Jordan. 314 Loss of fitness in vitro and in vivo associated with multiple mutations to fluoroquinolone resistance in Escherichia coli. MARCUSSON LL1, KOMP LINDGREN P1, SANDVANG D2, FRIMODT-MØLLER N2, HUGHES D1 1)Department of Cell and Molecular Biology, Microbiology Programme, Uppsala University, Uppsala, Sweden. 2)Statens Serum Institute, Copenhagen, Denmark. 656 Susceptible Escherichia coli Isolates Are More Virulent Than Multidrug-Resistant Isolates: An Experimental Study. A. ANTONOPOULOU, C. PANAGOU, D. PLACHOURAS, F. BAZIAKA, T. TSAGANOS, E. J. GIAMARELLOS- BOURBOULIS. 4th Department of Internal Medicine, Athens Medical School, Greece. 077 Rational Approaches to Overcome Selectivity and Multidrug Resistance Problems in the Design of Antifungal Agents. BOROWSKI E1, CYBULSKA B1, MAZERSKI J1, BAGINSKI M1, GRZYBOWSKA J1, MILEWSKI S1, ANDRUSZKIEWICZ R1, BOLARD J2 1Gdansk University of Technology, Gdansk, Poland; 2CNRS ESA 7033 Pierre and Marie Curie University, Paris, France. 056 Evolution of resistance to expanded-spectrum cephalosporins due to extended-spectrum ?-lactamases in Dubrava Hospital, Zagreb. BEDENIC B1, SCHMIDT H2, HEROLD S2, MONACO M3, PLECKO V4, KALENIC S4 1"A. Stampar" School of Public Health, Medical School, University of Zagreb, Croatia, 2Institute of Microbiology and Hygiene, Technical University Dresden, Germany, 3Instituto Superiore di Sanita, Rome, Italy, 4Clinical Hospital Center, Zagreb, Croatia. 131 Conjugative Transfer of Plasmid Encoding Extended-Spectrum ?-Lactamase (ESBL) between Clinical Salmonella Isolates. SAROWSKA J1, DRULIS-KAWA Z 2 , JANKOWSKI S1, DOROSZKIEWICZ W2 1 Departament Biology and Medical Parasitology, Medical University, Wroclaw, Poland; 2 Institute of Genetic and Microbiology, University of Wroclaw, Poland. 495 Drug resistance patterns of bacterial pathogens causing urinary tract infection at Tehran Torfeh Hospital during 2002- 2003. SHAHCHERAGHI FRESHTEH1, FEIZABADI MOHAMAD MEHDI2 1-Department of Bacteriology, Pasteur Institute of Iran, IR, Iran 2-Department of Biological science, Alzahra University, Vanak, Tehran, Iran. Category: Analytical techniques 287 Low Level Quantitative Analysis of Amoxicillin (AMO) in Plasma. LANDERSDORFER C1, KINZIG-SCHIPPERS M1, HOLZGRABE U2, SKOTT A1, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg; 2Institut für Pharmazie und Lebensmittelchemie, University of Würzburg, Würzburg, Germany. 516 Sensitive Analysis of Roxithromycin in Human Plasma by LC-MS/MS. KINZIG-SCHIPPERS M1, LANDERSDORFER C1, JAKOB V1, RODAMER M1, SKOTT A1, HOLZGRABE U2, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg; 2Institut für Pharmazie und Lebensmittelchemie, University of Würzburg, Würzburg, Germany. 194 METHODS OF RAPID DETECTION OF URINARY TRACT INFECTIONS, THE CAPILLARY ISOELECTRIC FOCUSING AND DIRECT MICROPY. V. Holá1, F. Ružicka1, M. Horká2, K. Šlais2 1Institute for Microbiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic 2Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Brno, Czech Republic. 254 Determination of Tolbutamide and its Two Metabolites in Human Urine by LC-MS/MS. KINZIG-SCHIPPERS M1, FAST D2, BREAU A2, HOLZGRABE U3, SÖRGEL F1 1Institute for Biomedical and Pharmaceutical Research, Nürnberg, Germany; 2G. D. Searle & Co., Skokie, IL, USA; 3Institut für Pharmazie und Lebensmittelchemie, University of Würzburg, Würzburg, Germany. 335 Rapid and Sensitive Determination of an Anti-infective AgNO3 in Biological Samples using Electrospray Mass Spectrometry. MINAKATA K, SUZUKI O Hamamatsu University School of Medicine, Hamamatsu, Japan. 372 CHEMICAL STABILITY OF CASPOFUNGIN IN CONCENTRATES AND INFUSION BAGS DETERMINED BY HIGH- PRESSURE LIQUID CHROMATOGRAPHY. Nguyen TH, Rosenhagen M, Hoppe-Tichy T Pharmacy of the University Hospital Heidelberg, Heidelberg, Germany. 376 HPLC Determination of Tigecycline in Human Samples. C. LI, C. SUTHERLAND, C.H. NIGHTINGALE, D.P. NICOLAU Ctr. for Anti-Infective Res. and Dev., Hartford Hosp., Hartford, CT. 461 IDENTIFICATION OF THE YEASTS BY CAPILLARY ELECTROPHORETIC TECHNIQUES WITH USE OF DYNAMIC MODIFICATION OF THE CELLS BY FLUORESCENT STAIN. F. Ružicka1, V. Holá1, M. Horká2, K. Šlais2 1Institute for Microbiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic 2Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Brno, Czech Republic. 464 Staining Plasmodium falciparum Histidine Rich Protein II (Pf HRPII) for High Through Put (HTP) Discovery of Blood Stage Antimalarials. SAHAL D, KANNAN R, KUMAR K, CHAUHAN V S Malaria Research Laboratory, International Center for Genetic Engineering & Biotechnology, New Delhi, India. 654 Real Time RT-PCR: A method for the assessment of immun-response on mRNA level. A case study on fosfomycin. JOKHADAR C1,2, JILMA B1, STEINER I1, MÜLLER M1, WAGNER O3, MARSIK C1,3 1Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, 2Institute of Pharmacology, 3Institute of Medical and Chemical Laboratory Diagnostics; all Medical University of Vienna, Vienna, Austria. 661 Determination of the Extent of the Protein Binding of Antibiotics by Means of Automated Continuous Ultrafiltration. HEINZE A, HOLZGRABE U Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Germany. Category: Antineoplastic agents - new and known synthetic compounds 208 Studies on New Tumour Active Compounds with Three Metal Centres. HUQ F1, DAGHRIRI H2, BEALE P3, YU JQ1 1School of Biomedical Sciences, University of Sydney, Sydney, Australia; 2RPAH, Camperdown Sydney Australia. 544 Metal-Complexes as Chemotherapeutic Agents. THEOPHANIDES T1,2 ANASTASSOPOULOU J1 THEODORACOPOULOU O1 1National Technical University of Athens, Chemical Engineering School, Radiation Chemistry and Biospectroscopy, Zografou Campus, Zografou Athens. 2International Institute of Anticancer Research, Kapandriti-Kalamou, Greece. 184 The Influence of Ring-Closing Processes on the Activity of New pH-Sensitive Platinum Anti-Tumour Agents. HARTINGER CG1, SCHLUGA P1, GALANSKI M1, JAKUPEC MA1, KEYSERLINGK N GRAF VON2, KEPPLER BK1 1Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria 2Faustus Forschung Austria Translational Drug Development AG, Vienna, Austria. 031 Correlation of In Vitro Potency and Reduction Potential of Tumour-Inhibiting Ruthenium Complexes. ARION VB, JAKUPEC MA, REISNER E, EICHINGER A, PONGRATZ M, GALANSKI M, HARTINGER CG, KEPPLER BK Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria. 532 Interaction of Radiation and Anticancer Drug (Cisplatin, Etoposide) on Two Cell Lines with Different Radiosenseitivities In Vitro (especially Apoptosis. Takahashi T1, Mitsuhashi N2, Akimoto T3, Matsumoto H3, Ishikawa H3, Nakano T3 1Dept. of Radiol., Saitama Med. Center, Saitama Med. Sch., Kawagoe, Japan; 2Dept. of Radiol., Tokyo Women,s Medical Univ., Tokyo, Japan; 3Dept. of Radiol. & Radiat. Oncol., Gunma Univ. Sch. of Med., Maebashi, Japan. 025 Quinoxaline Derivatives, FM-04 and FM-05, Inhibit DNA Topoisomerase I and Induce Apoptosis in a Panel of Human Cancer Cell Lines. Andoh T1, Yamamoto M1, Kato T2, Yamori T3 1Soka University, Tokyo, 2Tohoku Pharmaceutical University, Sendai, 3Foundation for Cancer Research, Tokyo, Japan. 273 3-Carboxy-4-(1H)-quinolones as Inhibitors of Human Protein Casein Kinase 2 (CK2). KOSTENKO A, YAKOVENKO O, GOLUB A, BDZHOLA V, SAPELKIN V, and YARMOLUK S Institute of Molecular Biology and Genetics of NAS of Ukraine, Ukraine, Kyiv. 527 Sulfonamides as anti-tumor agents: novel mechanisms of action and new pharmacological agents in development. Claudiu T. Supuran Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Sesto Fiorentino (Florence). 553 Antitumor effects of water soluble phenoxazine on various carcinoma cells in vitro and in vivo. TOMODA A Department of Biochemistry, Tokyo Medical University, Tokyo, Japan. 140 Invention of a novel oral antimetabolite named TAS-102 by biochemical modulation of trifluorothymidine (FTD) with newly synthesized thymidine phosphorylase inhibitor (TPI). EMURA T, YOKOGAWA T, KITAZATO K, FUKUSHIMA M, TERADA T Hanno Research Center, Taiho Pharmaceutical Co., Ltd., Saitama, Japan. Category: Antineoplastic agents - new and known non- synthetic compounds 321 Anti-angiogenic activity of vitamin B6. KIMINORI MATSUBARA1, REIKO AKAGI1, MASAHARU MORI1, NORIHISA KATO2 1Okayama Prefectural University, Okayama, Japan; 2Hiroshima University, Hiroshima, Japan. 607 Anti-metastatic effects of polysaccharide-K (PSK) in colorectal carcinoma cells by protein microarray analysis. Yoshikawa R1,2, Yanagi H1, Noda M1, Yamamura T1,2 , Okamura H2, Hashimoto-Tamaoki T2,3. 1Second Department of Surgery; 2Institute for Advanced Medical Sciences; 3Department of Genetics, Hyogo College of Medicine, Nishinomiya, Hyogo, JAPAN. 313 Could FGF-1 be a "magic bullet"? A very preliminary studies in vitro. MARCINKOWSKA E, SUPERAT K. Institute of Biochemistry and Molecular Biology, University of Wroclaw, Poland. 156 Antitumour Activity of Cyanidin-3-O-?-Glucopyranoside: Effects on Human Transformed and Non-Transformed Cell Lines. FIMOGNARI C1, BERTI F1, NÜSSE M2, CANTELLI-FORTI G1, HRELIA P1 1University of Bologna, Bologna, Italy; 2GSF-National Research Center for Environment and Health, Neuherberg, Germany. 154 Plant Jasmonates – A Novel Class of Anti-Cancer Molecules. FLESCHER E Tel Aviv University, Tel Aviv, Israel. 307 The Effect of Phorbol Ester in a Wide Range of Concentration on the Membranes of Ehrlich Ascite Carcinoma Cells in vitro. MAL'TSEVA EL, Pynzar EI, Pal'mina NP Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. 613 An overview of anticancer phytotherapy using Viscum album extract Isorel: Novel findings of simultaneous anticancer and anti-diabetic effects in mice bearing solid form of Ehrlich Ascytic Tumor. Neven Zarkovic Rudjer Boskovic Institute, Div. of Molecular Medicine, Zagreb, Croatia: 075 Effect of recombinant human interleukin 2 (rIL2) pretreatment on oral paclitaxel toxicity and activity on murine Lewis Lung Carcinoma. BONHOMME-FAIVRE L1,2, HOSTEN B2, ABBARA C1, GIL S2, MARION S1 CHALLUAU D3, ARDOUIN P3, FARINOTTI R2 1 Paul Brousse Hospital, Department of Pharmacy, Villejuif, France AP-HP; 2Laboratory UPRES EA 2706, Chatenay Malabry, France ; 3 Institut Gustave Roussy, Villejuif , France. 528 Combined Antitumor Activity of Extracts from Cyanobacterium Anabaena cylindrica with Some Anticancer Agents. SUZUKI T1, EZURE T2, NAKAMURA Y2, POMATI F3, MANAROLLA G3, ROSSETTI C3, FABIAN WMF4 1Toyo University, Asaka, Japan; 2Tokyo Institute of Technology, Yokohama, Japan; 3University of Insubria, Varese, Italy; 4Karl-Franzens Universität Graz, Graz, Austria. 386 Granulocyte Colony-Stimulating Factor (G-CSF) Mobilizes Bone Marrow (BM)-Derived Endothelial Progenitor Cells (EPCs) for Ischemic Neovascularization. OHSAKA A1, OHKI Y1, HEISSIG B2, HATTORI K2, DAIDA H1 1Juntendo University School of Medicine, Tokyo, Japan; 2Institute of Medical Science, University of Tokyo, Tokyo, Japan. 197 Antineoplastic Strategy: Irreversible Tumor Blood Flow Stasis Induced by the Combretastatin A-4 Derivative AVE8062 (AC7700). HORI K1 1Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. Category: Antineoplastic agents - clinical studies 134 Thermochemotherapy: combining hyperthermia with cytotoxic chemotherapy. DVORAK J, ZOUL Z, MELICHAR B, VESELY P Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic. 611 Non-organ Specific Cancer Preventive Effects of Panax ginseng C.A. Meyer: A Prospective Study for 10 Years. YUN T-K Korea Institute for Cancer Chemoprevention, Seoul, Korea. 083 Clinical Application of Body Epigenetic System. Multi-Targeted Therapy for Primary Brain Tumors. BURZYNSKI SR, JANICKI T, WEAVER R, JURIDA G, SZYMKOWSKI B, KHAN M, DOLGOPOLOV V. Burzynski Clinic, Houston, USA. 402 Trifolium Pratense for breast diseases – clinical studies (a case series). PÂRVU E. The Acupuncture and Homeopathic Centre ,Bucharest, Romania. 444 Identification and Validation of Biomarkers of Phyto-oestrogen Exposure and their Application in Breast Cancer Investigations. RITCHIE MR1, MORTON MS2, DEIGHTON N3, BLAKE A3, STEWART D3, CUMMINGS JH4, STEEL,CM1, RICHES A1 1Bute Medical School, University of St. Andrews, Scotland; 2Department of Clinical Biochemistry, University of Wales, Cardiff; 3Scottish Crop Research Institute, Invergowrie, Scotland; 4 Division of Pharmacology and Neurosciences, University of Dundee, Scotland. 189 Water-in-Oil-in-Water Emulsion for Transcatheter Arterial Embolization Therapy for Hepatocellular Carcinoma. HINO T1, KAWASHIMA Y2, SHIMABAYASHI S1 1The University of Tokushima, Tokushima, Japan; 2Gifu Pharmaceutical University, Gifu, Japan. 509 Molecular Markers Identify High Grade Prostatic Intraepithelia Neoplasia (HGPIN) Precursor to Prostate Cancer (PC): Selection of Patients for Repeat Biopsy. SINHA AA1, 2, Betre, K1, Lall V1, Ewing SL2, 3, Wilson MJ3, Qian J4, Bostwick DG4, 5 1Depts. of Genetics, Cell Biol. & Develop., 2VA Research Service, 3Lab. Med. & Pathol., Univ. of Minnesota, Minneapolis, MN and 4Bostwick Laboratories, Richmond VA and 5Univ. of Virginia, Charlottesville, VA, USA. 647 Activity of cladribine combined with etoposide in heavily pretreated patients with indolent lymphoid malignancies. ROBAK T, SZMIGIELSKA-KAPLON A, BLONSKI JZ, KASZNICKI M, CHOJNOWSKI K. Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland. 648 The Place of Cladribine in the Treatment of Chronic Lymphocytic Leukemia – Polish Experience. ROBAK T. Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland. Category: Pharmacokinetics and tissue penetration of antineoplastic agents 277 DOXO-EMCH, the First Albumin-binding Doxorubicin Prodrug to Enter Phase I Clinical Trials. MEDINGER M, MROSS K, KRATZ F, HÄRING B, UNGER C, DREVS J Tumor Biology Center, Freiburg, Germany. 407 The Blood-Testis Barrier as a Target of some Chemotherapeutic Agents. Pereira ML1 and Garcia e Costa F2 1University of Aveiro, Aveiro, Portugal; 2 Faculty of Veterinary Medicine, Technical University of Lisbon, Portugal. 074 Population Pharmacokinetic (PK) Modeling and Therapeutic Drug Monitoring (TDM) of High-dose (HD) Methotrexate (MTX) for Osteosarcoma. BONDAREVA I1, SINGIN A2 1The Research Institute of Physical-Chemical Medicine, Moscow, Russia; 2Russian Research Cancer Center, Moscow, Russia. 291 Population Pharmacokinetics of Intravenous Etoposide: Is there an Influence of Dose? CHARANEK W1, LENTZ F1, GRASMAEDER K1, REIF S2, JAEHDE U1 1Inst. of Pharmacy, Dept. Clinical Pharmacy, University of Bonn, Germany; 2Inst. of Pharmacy, Dept. Clinical Pharmacy, Free University of Berlin, Germany. 130 Dose Individualization Can Minimize Nephrotoxicity Due to Carboplatin Therapy in Ovarian Cancer Patients. DONADIO C1, LUCCHESI A1, ARDINI M1, COSIO S2, FANUCCHI A2, GADDUCCI A2 1Department of Internal Medicine – Nephrology; 2Department of Gynecology, University of Pisa, Pisa, Italy. Category: Mechanism of tumor development and growth 457 Therapeutic Effects of Local Administration of Caroverine on Noise-induced Hearing Loss in Guinea Pig. CHEN Zhiqiang a, b,DUAN Maoli b,RUAN Runsheng a,ULFENDAHL Mats b, TAN Luke a a Department of Otolaryngology, National University of Singapore, Lower Kent Ridge Road, Singapore b Department of Clinical Neuroscience and Center for Hearing and Communication Research, Karolinska Institutet, Stockholm, Sweden. 638 Specific DNA Labelling Based on Cooperative Hybridization of the Functional DNA Conjugates. IHARA T1, FUJII T1, MUKAE M1, KITAMURA Y1, OKADA K1, TAZAKI M2, JYO A1 1Kumamoto University, Kumamoto, Japan; 2Sojo University, Kumamoto, Japan. 295 Hypermethylation of hMLH1 Promoter Represents a Major Mechanism for the Presentation of High-Frequency Microsatelite Instability (MSI-H)in the Early-Onset Colorectal Cancer of Taiwan. LIANG JT Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan. 572 The Significance of Serum Copper Levels in the Myelodysplastic Syndromes. JUDIT VÁRKONYI 1, TERÉZIA SZABÓ 2, PIROSKA SEBESTYÉN 2, ATTILA TORDAI3, HAJNALKA ANDRIKOVICS3, PÉTER FARKAS 1, SZABOLCS BENEDEK 1, GÁBOR TARKOVÁCS 1, ISTVÁN KARÁDI 1. 1. Semmelweis University, Budapest, Hungary 2. Heim Pál Hospital, Budapest, Hungary 3. National Institute of Hematology and Immunology, Budapest, Hungary. 163 Reactivity of Novel Albumin-Binding Platinum Complexes. GARMANN D1, WARNECKE A2, KRATZ F2, JAEHDE U1 1Inst. of Pharmacy, Dept. Clinical Pharmacy, University of Bonn, Germany; 2Tumor Biology Center, Freiburg. 534 Circumvention of Antifolate-Resistance by Rationally Designed New Analogues: the Relationship between Structural Modification and Pharmacological Property and Its Clinical Implications. TAKEMURA Y National Defense Medical College, Tokorozawa, Japan. 520 Chemosensitivity changes at different ribosomal protein (S3a) mRNA levels and cell densities in various cell lines. SORIMACHI K, NEMOTO K, AKIMOTO K, SUNAGAWA M Dokkyo University School of Medicine, Mibu, Japan. 642 Choice of Bleomycin on the Basis of Polyamine Level in Various Regions of the brain in rats. NAGASE S1, WATANABE S2, SATO S1, OHKUMA S2 1 Kawasaki College of Allied Health Professions, Okayama, Japan, 2 Kawasaki Medical School, Okayama, Japan. Category: Mechanisms of action of antineoplastic agents including resistance 125 Cellular Factors of Multidrug Resistance (MDR) – New Strategies of Evaluation. DIACONU C.C1, CHIVU M1, BLEOTU C1, ALEXIU A1, ANTON G1, PLESA A1, BRASOVEANU L2, AND CERNESCU C1 1"Stefan S. Nicolau" Institute of Virology, Bucharest, Romania, 2Center of Immunology, Bucharest, Romania. 460 The Cancer Cell's "Bullet Proof Vest": Inactivation of Ceramide Signaling Pathways Promotes Chemoresistance. Ruvolo, PP1 1University of Texas Health Science Center, Institute of Molecular Medicine, Houston, USA. 507 High-level functional expression of human P-glycoprotein in yeast cells with high fluidity plasma membranes leads to resistance against Aureobasidin A. SIEVERS JG1, AL-SHAWI MK2, WIESE M1 1 University of Bonn, Germany, Medical Chemistry 2 University of Virginia, Charlottesville, USA, Department of Molecular Physiology and Biological Physics. Category: Vaccination 127 Delivery of DNA Vaccines by Attenuated Live Bacterial Vaccines. Dietrich G. Berna Biotech Ltd, Berne, Switzerland. 476 Cytoskeletal Targets for the Development of Vaccines in Apicomplexan Parasites. SCHATTEN H1 1Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, MO, USA. Category: Mechanisms of pharmacological importance 220 The Nociception/Antinociception of Sodium Channels Modulators Originating from Buthus martensi Karsch (BmK) Venom on the Inflammatory Pain. Jin CHEN, Xu-Ying ZHANG, Zhan-Tao BAI, Zhi-Yong TAN, Yong-Hua JI The Key Laboratory of Neurobiology, Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China. 312 AN APPROACH TO ASSESS HAZARD OF CHEMICAL MIXTURES IN A QUALITATIVE AND QUANTITATIVE MANNER USING EXPERIMENTAL ANIMALS AND DEFINITE DOSES. SAMEEH A. MANSOUR Pesticide Chemistry Department, National Research Centre, Dokki, Cairo, Egypt. 454 Chemotherapy for Osteoarthritis? ROZIN AP, MILITIANU D, EDOUTE Y Rambam Medical center and B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. 533 A new polysaccharide lyase that acts on a basic polysaccharide, producing an oligosaccharide terminating in unsaturated amino sugar residue. TAKEDA M, MAKITA H, NAKAHARA Y, NOGAMI T, KOIZUMI J Division of Materials Science and Chemical Engineering, Faculty of Engineering, Yokohama National University, Yokohama, Japan. 110 Leukocytes as "Magic Bullets" Against Cancer Cells in Cancer-resistant SR/CR Mice. Zheng Cui, Mark C Willingham and Amy M. Hicks Department of Pathology, Wake Forest University School of Medicine Winston-Salem, North Carolina, USA. 462 Estimation of Chemotherapy Effectiveness Using Chromosome Aberration Analysis in the Peripheral Human Blood Lymphocytes. DYOMINA EA, RYABCHENKO NM Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Kyiv. Category: Diagnostic tests in cancer / adverse events of cancer treatment 143 Diagnostic Value of Silver Nitrate Staining for Nucleolar Organizer Regions (NORs) in Selected Head and Neck Tumors. Eslami B1, Rahimi F1, Rahimi H2, Moradzadeh Khiavi M3, Tahernia R2 1Shahid Behesti University of Medical Sciences, Tehran, Iran, 2Iran Center for Dental Research, Tehran, Iran, 3Tabriz University of Medical Sciences, Tabriz, Iran. Category: Adverse events of antineoplastic compounds 258 Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin in rats. Ahmet Kizilay1, M. Tayyar Kalcioglu2, Elif Ozerol3, Mustafa Iraz4, Mukaddes Gulec3, Omer Akyol5, Orhan Ozturan6 1,2,6Departments of Otorhinolaryngology; 3,5Department of Biochemistry; 4Department of Pharmacology; Inonu University School of Medicine, Malatya, TURKEY 602 Efficacy of Shakuyaku-kanzo-to in the Treatment of Paclitaxel-induced Muscle Pain —VAS Assessment. YAMAMOTO K1, HIRANO F1, IKOMA N1, ABE K, HOSHIAI H, NODA K Sakai Hospital1, Kinki University School of Medicine, Osaka, Japan. 599 Cancer Chemotherapy-Induced Intestinal Mucositis: Mechanisms of Mucosal Damage and Healing. XIAN CJ Department of Orthopaedic Surgery, and University of Adelaide Department of Paediatrics, Women's and Children's Hospital, North Adelaide, Australia. Category: Blood brain barrier 045 Cerebrospinal Fluid Dynamics an Relation with Blood Flow. OLIVIER BALÉDENT Department of Imaging and Biophysics, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France. 609 Nanoparticles for Chemotherapy across the Blood Brain Barrier – Effects of Emulsifier and Particle Size. YU Q, CHEN L, FENG SS Chemotherapeutic Laboratory, National University of Singapore, Singapore. 342 Distribution of the Aquaporin Water Channels AQP1, AQP3 and AQP4 in the Human Choroid Plexus; Implications for Water Transport in the Brain. MOBASHERI A1, MARPLES D2 1Molecular Pathogenesis and Connective Tissue Research Groups, Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, United Kingdom. 2School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom. 443 Insulin-like Growth Factor-1 (IGF-1) Delivery Across the Blood-Brain Barrier (BBB). R S RIIKONEN Children`s Hospital, University of Kuopio, FINLAND. 009 Applications of a Blood-Brain Barrier Technology Platform to predict CNS penetration of drugs in various series of therapeutics families. II. In vitro model of rat blood-brain barrier. PERRIERE N1,2, ADENOT M1, LAHANA R1, SCHERMANN JM2, ROUX F2 1Synt:em, Nîmes, France; 2 INSERM U26, Hôpital F.Widal, France. 511 Etoposide Pharmacokinetics in Cerebrospinal Fluid (CSF) After Different Intraventricular Dosage Regimens. SIRISANGTRAGUL C1, HENKE G1, FLEISCHHACK G2, REIF S3, BODE U2, JAEHDE U1 1Inst. of Pharmacy, Dept. Clinical Pharmacy, University of Bonn 2Dept. of Paediatric Haematology/Oncology, University of Bonn 3Inst. of Pharmacy, Dept. Clinical Pharmacy, Free University of Berlin, Germany. Category: Targeted delivery of antineoplastic agents 044 Cryopreservation of Peripheral Blood Stem Cells (PBPC) Frozen with 5% instead of 10% DMSO Give Better or no Differences in Colony Formation and Less Apoptosis and Necrosis in CD34+ Cells. BAKKEN AM1, Abrahamsen JF1, Bruserud Ø2 1The Blood Bank and 2Division of Hematology, Haukeland University Hospital, Bergen, Norway. 274 Enhanced Cell-Surface Expression of MMPs and Their Inhibitors, and Tumor-Induced Host Response in Progression of Human Gastric Carcinoma. KOYAMA S. Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan. 650 Gene Manipulation by Photo-Sensitive Chemical Agents. HIDEKI ANDO1, TOSHIAKI FURUTA2, HITOSHI OKAMOTO1 1Lab. for Developmental Gene Regulation, Brain Science Institute, RIKEN (The Institute of Physical and Chemical Research), Japan. 2Dep. Biomolecular Science, Toho University, Japan. 392 Non-Transcriptional Functions of STATs in Tumor Cells – Possible Target for Antineoplastic Therapy? ORZECHOWSKI A, PAJAK B Department of Physiological Sciences, Warsaw Agricultural University, Faculty of Veterinary Medicine, Warsaw, Poland. 546 Novel Acoustic Liposomes for Drug Encapsulation. TIUKINHOY SD, HUANG SL, KHAN AA, MACDONALD RC, MCPHERSON DD. Northwestern University, Chicago/Evanston, Illinois, USA. 393 Behind the Scenes of Cycloheximide-Mediated Sensitization of Colorectal Cancer Cells to TNF?-Induced Apoptosis. 1PAJAK B, 2GAJKOWSKA B, 1ORZECHOWSKI A 1Department of Physiological Sciences, Warsaw Agricultural University, Faculty of Veterinary Medicine, Warsaw, Poland; 2Department of Cell Ultrastructure MRC, Polish Academy of Sciences, Warsaw, Poland. 429 Alpha-fetoprotein-vehicled targeted delivery of doxorubicin and antisenses to tumor cells. 1POSYPANOVA GA, 3NITSVETOV MB, 1MOSKALEVA EYu, 2KIREEVA NN, 1RODINA AV, 1POPOVA ON, 1SEVERIN SE, 2SEVERIN ES. 1Moscow Research Institute of Medical Ecology, 2Russian Research Center for Molecular Diagnostics and Therapy, 3IM Sechenov Moscow Medical Academy, Moscow, Russia 587 Chemotherapeutic Targeting of Ranimustine (MCNU) or Nimustine (ACNU) to Various Tissues on the Basis of Polyamine Level. WATANABE S1, SATO S2, NAGASE S2, OHKUMA S1 1Kawasaki Medical School, Okayama, Japan, 2Kawasaki College of Allied Health Professions, Okayama, Japan, Category: Role of cells and their staining by dyes 405 New Antiulcer and Antiinflammatory Agents Inhibit Compound 48/80-Induced Mast Cell Degranulation. PENISSI AB1, RUDOLPH MI2, PIEZZI RS1 1Insituto de Histología y Embriología (IHEM-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina; 2Departamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile. 645 Mast cell (MC) as a significant contributor to the physiological response under different extreme exposures. GRAEVSKAYA EE1, ACHALAYA MY1, YASUTAKE A.2, ARAMAKI R.2, RUBIN AB.1 1Dept. Biophysics, Biological Faculty, Moscow State University, Moscow, Russia, 2National Institute for Minamata Disease, Minamata, Kumamoto, Japan. Category: Agents involving the immune system 169 GANGLIOSIDES-BASED CANCER VACCINES: TOXICOLOGICAL ASSAYS. A Bada1, A Casacó2, A Mancebo1, B González1*, D Fuentes1, O Hernández1, ME Arteaga1, J Hernández1, C González1, N Subirós1, Y González1, C Mesa2, LE Fernández2 1Expositor address . National Center for Breeding of Laboratory Animals, CENPALAB. Finca Tirabeque, Bejucal, La Habana. Cuba. 2Center of Molecular Immunology. 170 Perspectives of combined radioimmunotherapy and anti- EGFR antibody, h-R3, therapy for the treatment of solid tumors of neuroephitelial origen. Barbara O. Gonzalez Navarro1*, Angel Casaco Paradas2, Nelvis Subiros Martinez1, Rene Leyva Montana3, Mariela Leon Perez3, Osvaldo Hernandez Sosa1, Juana Hernandez Estrada1, Irene Bosulei2, Alejandro Perera Pintado4, Magdalena Legro Soto1 1National Center for Breeding of Laboratory Animals, CENPALAB. Finca Tirabeque, Bejucal, La Habana. Cuba. 2Center of Molecular Immunology 3 Isotopes Center 4 Clinical Research Center. 523 Overview of Effectiveness of Rabies Antibodies in Rabies Postexposure Prophylaxis. STANKOV S, VRANJES N, AND DESNICA J Pasteur Institute, Novi Sad, Serbia and Montenegro. Category: About mechanisms and Magic Bullets 066 The Efficacy of Tacrolimus in the Management of Focal Segmental Glomerulosclerosis. R Bhimma, M Adhikari, K Asharam, CA Connolly. University of Kwazulu-Natal, Kwazulu-Natal, Durban, South Africa. 456 Protective Effects of Local Administration of Caroverine on Noise-induced Hearing Loss in Guinea Pigs. CHEN Zhiqiang a, b,DUAN Maoli b,RUAN Runsheng a,ULFENDAHL Mats b, TAN Luke a a Department of Otolaryngology, National University of Singapore, Lower Kent Ridge Road, Singapore b Department of Clinical Neuroscience and Center for Hearing and Communication Research, Karolinska Institutet, Stockholm, Sweden. 658 Th1/Th2 cytokine balance: in what way pregnancy is similar to cancer? JACEK R. WILCZYNSKI1 Polish Mother's Health Center Research Institute, Lodz, Poland. World Conference on Magic Bullets Celebrating Paul Ehrlich's 150th Birthday Nürnberg, Germany, September 9-11, 2004 Number on the left shows where abstract will appear in the abstract book. Program P-1